Topical Compositions Comprising Inorganic Particulates And An Alkoxylated Diphenylacrylate Compound

• US 20110110988A1
• Filed: 04/30/2010
• Published: 05/12/2011
• Est. Priority Date: 05/04/2009
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Najdek, Linda Josephine, Ionita-Manzatu, Mirela Cristina, Susak, Milanka, Syed, Ismail Ahmad
• Granted Patent: US 8,765,156 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 47/06 Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/5026 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

A topical composition of improved spreadability and aesthetical appeal is provided, which contains inorganic particulates in combination with an alkoxylated diphenylacrylate compound. Preferably, the topical composition is a sunscreen composition that contains inorganic or physical sunscreen agents in combination with an alkoxylated α-cyanodiphenylacrylate compound, which is characterized by improved photo-protection of the skin and is effective in preventing/reducing photo-damage of the skin upon exposure to sunlight or other sources of light in the ultraviolet (UV), visible, and infrared (IR) ranges.

Claims

1. A topical composition comprising at least one inorganic particulate material and an alkoxylated diphenylacrylate compound in a pharmaceutically or cosmetically acceptable carrier.

2. The topical composition of claim 1, wherein the at least one inorganic particulate material comprises at least one metal oxide.

3. The topical composition of claim 1, wherein the at least one inorganic particulate material comprises a physical sunscreen agent selected from the group consisting of titanium dioxide particles, zinc oxide particles, and mixtures thereof.

4. The topical composition of claim 1, wherein the alkoxylated diphenylacrylate compound is an alkoxylated α

-cyanodiphenylacrylate having the formula (I);

5. The topical composition of claim 4, wherein one or both of R₁ and R₂ is a straight or branched-chain C₁-C₈ alkoxy radical.

6. The composition of claim 1, wherein the alkoxylated diphenylacrylate compound is an alkoxylated α

-cyanodiphenylacrylate having the formula (III), (IV) or (V);

7. The topical composition of claim 1, wherein the alkoxylated diphenylacrylate compound is α

-ethylhexyl α

-cyano-β

-(4-methoxyphenyl)-β

-phenylacrylate.

8. The topical composition of claim 1, wherein the at least one inorganic particulate material is entrapped by collapsed polymeric shells to form microspheres having an average particle size ranging from about 1 micron to about 50 microns.

9. The topical composition of claim 1, further comprising one or more organic or chemical sunscreen agents selected from the group consisting of 4,4′

-t-butyl methoxydibenzoylmethane, 2-ethylhexylsalicylate, 3,3,5-trimethylcyclohexylsalicylate, 2-ethylhexyl p-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2,2-dihydroxy-4-methoxybenzophenone, 2,4-bis-{4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, terephthalylidene dicamphor sulfonic acid, diethylhexyl 2,6-naphthalate, digalloyltrioleate, ethyl 4-[bis(hydroxypropyl)]aminobenzoate, glycerol p-aminobenzoate, methylanthranilate, p-dimethylaminobenzoic acid or aminobenzoate, 2-ethylhexyl p-dimethylaminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2-(p-dimethylaminophenyl)-5-sulfoniobenzoxazoic acid, and mixtures or combinations thereof.

10. The topical composition of claim 1, which is substantially free of any organic or chemical sunscreen agent selected from the group consisting of 4,4′

-t-butyl methoxydibenzoylmethane, 2-ethylhexylsalicylate, 3,3,5-trimethylcyclohexylsalicylate, 2-ethylhexyl p-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2,2-dihydroxy-4-methoxybenzophenone, 2,4-bis-{4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, terephthalylidene dicamphor sulfonic acid, diethylhexyl 2,6-naphthalate, digalloyltrioleate, ethyl 4-[bis(hydroxypropyl)]aminobenzoate, glycerol p-aminobenzoate, methylanthranilate, p-dimethylaminobenzoic acid or aminobenzoate, 2-ethylhexyl p-dimethylaminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2-(p-dimethylaminophenyl)-5-sulfoniobenzoxazoic acid, and mixtures or combinations thereof.

11. The topical composition of claim 1, which is substantially free of 4,4′

-t-butyl methoxydibenzoylmethane.

12. The topical composition of claim 1, further comprising at least one DNA repair enzyme.

13. The topical composition of claim 1, further comprising glycerin or a C2-C4 alkylene glycol.

14. The topical composition of claim 1, further comprising methyl trimethicone.

15. A topical composition having an SPF ranging from about 15 to 100 comprising α

-ethylhexyl α

-cyano-β

-(4-methoxyphenyl)-β

-phenylacrylate, an inorganic particulate selected from the group consisting of zinc oxide, titanium dioxide, and mixtures thereof.

16. The topical composition of claim 15, wherein the inorganic particulate is entrapped by collapsed polymeric shells to form microspheres having an average particle size ranging from about 1 micron to about 50 microns.

17. The topical composition of claim 15, further comprising at least one nonvolatile silicone having a viscosity ranging from about 5 to 250,000 centistokes at 25°

C.

18. The topical composition of claim 15, further comprising at least one silicone elastomer.

19. The topical composition of claim 15, further comprising trimethylsiloxysilicate.

20. The topical composition of claim 15, further comprising at least one volatile paraffinic hydrocarbon selected from the group consisting of isododecane, isohexadecane, and mixtures thereof.