METHODS AND COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
First Claim
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1. A prophylactic method for a neurological disorder comprising, administering a compound selected from Table 5 to a subject at risk of developing said disorder.
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Abstract
Methods and compositions are provided for preventing and treating neurological disorders, in particular Parkinson'"'"'s disease.
52 Citations
48 Claims
- 1. A prophylactic method for a neurological disorder comprising, administering a compound selected from Table 5 to a subject at risk of developing said disorder.
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4. A method of treating a subject at risk of developing a neurological disorder comprising, administering one or more compounds selected from Table 5 to said subject, wherein said subject does not show any primary symptoms associated with said disorder;
- and wherein said administering delays or prevents onset of primary symptoms of said disorder.
- View Dependent Claims (5, 6, 7, 8, 9, 10)
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11. A method of preventing or reversing α
- -synuclein fibrillation in a subject with or at risk of developing a neurological disorder comprising administering an effective amount of a compound that prevents or reverses α
-synuclein fibrillation, wherein said compound is selected from the group listed in Table 5. - View Dependent Claims (12, 13)
- -synuclein fibrillation in a subject with or at risk of developing a neurological disorder comprising administering an effective amount of a compound that prevents or reverses α
- 25. A method of treating Parkinson'"'"'s disease in a subject comprising administering to the subject an effective amount of any compound of Table 5 except apomorphine, levodopa, or benzerazide.
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30. A method of treating a subject at risk of developing a neurological disorder comprising, administering either a dopamine agonist, a monoamine oxidase inhibitor, a nutraceutical, or an inhibitor of α
- -synuclein fibrillation or any combination thereof to said subject, wherein said subject does not show any primary symptoms associated with said disorder; and
wherein said administering delays or prevents onset of primary symptoms of said disorder. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
- -synuclein fibrillation or any combination thereof to said subject, wherein said subject does not show any primary symptoms associated with said disorder; and
- 44. A method of treating a subject at risk of or suffering from a neurological disorder comprising, administering one or more compounds selected from Table 5 to said subject, wherein said administering decreases, delays, prevents, or reverses primary symptoms of said disorder.
Specification