METHOD AND COMPOSITION FOR IMPROVED ANABOLISM

• US 20110111066A1
• Filed: 11/09/2010
• Published: 05/12/2011
• Est. Priority Date: 11/09/2009
• Status: Active Grant

• Current Assignee: Glanbia Performance Nutrition Ltd.
• Original Assignee: Bio-Engineered Supplements & Nutrition Incorporated (Glanbia Company-Operative Society Limited)
• Inventors: Ferguson, Chris, Abraham, Sal
• Granted Patent: US 8,173,181 B2
• Time in Patent Office: Days
• US Class Current: 424/728
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/296 Epimedium
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26

Abstract

Nutritional compositions are provided containing at least one PPAR agonist, at least one PGC-1alpha agonist, and at least one creatine derivative. Methods of promoting anabolism and improving or enhancing physical performance using the compositions are provided. The compositions and methods can be combined with physical training or exercise.

Claims

1. A nutritional composition comprising at least one PPAR agonist, at least one PGC-1alpha agonist, at least one creatine derivative, and a nutraceutically acceptable carrier.

2. The nutritional composition of claim 1, wherein the PPAR is PPAR-alpha.

3. The nutritional composition of claim 2, wherein the at least one PPAR-alpha agonist is selected from one or more of the group consisting of Epimedium sagittatum, Epimedium grandiflorum, and sodium pyruvate.

4. The nutritional composition of claim 2, wherein the at least one PGC-1alpha agonist is selected from the group consisting of Epimedium sagittatum, Epimedium grandiflorum, sodium pyruvate, piceatannol, Rhodiola rosea, Japanese Knotweed, and combinations thereof.

5. The nutritional composition of claim 2, wherein the at least one PPAR-alpha agonist and the at least one PGC-1alpha agonist are the same component.

6. The nutritional composition of claim 1, wherein the creatine derivative is selected from the group consisting of creatine, creatine heptyl ester, creatine ethyl ester, creatinol-O-Phosphate, and a salt or a solvate thereof.

7. The nutritional composition of claim 6, further including at least one of a component selected from the group consisting of icariin, heptanol, heptaminol, L-lyxoflavin, Oxytropis muricata, hydroxyphenethylamine, N-benzoyl-2-hydroxyphenethylamine, N-nicotinoyl-2-hydroxyphenethylamine, Echeveria glauca, Rhodiola rosea, rosavin, salidroside, Panax gingseng, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid, alpha-hydroxy-beta-methyl valeric acid, alpha-hydroxy-gamma-methylthiobutyric acid, alpha-hydroxy-beta-phenylpropionic acid, alpha-hydroxy-beta-imidazolepropionic acid, alpha-hydroxy-beta-hydroxybutyric acid, alpha-hydroxy-gamma-aminocaproic acid, alpha-hydroxy-gamma-guanidinovaleric acid, kamferol-3,7-dirhamnoside, Shilajit moomiyo extract, humic acid, fulvic acid, Kudzu (Pueraria lobata), robinin, Hawthorn (Crataegus monogyna), hyperin, Loquat leaf extract, maslinic acid, and mixtures thereof.

8. A method for increasing anabolism in a human subject during physical activity, the method comprising administering to the subject an effective amount of a nutritional composition comprising at least one PPAR agonist, at least one PGC-1alpha agonist, at least one creatine derivative, and a nutraceutically acceptable carrier, wherein the anabolism of the subject is increased.

9. The method of claim 8, wherein the effective amount of the nutritional composition is a daily dose from about 1 gram to about 100 grams.

10. The method of claim 8, wherein the PPAR is PPAR-alpha.

11. The method of claim 10, wherein the at least one PPAR-alpha agonist is selected from one or more of the group consisting of Epimedium sagittatum, Epimedium grandiflorum, and sodium pyruvate.

12. The method of claim 10, wherein the at least one PGC-1alpha agonist is selected from the group consisting of Epimedium sagittatum, Epimedium grandiflorum, sodium pyruvate, piceatannol, Rhodiola rosea, and Japanese Knotweed.

13. The method of claim 8, wherein the creatine derivative is selected from the group consisting of creatine, creatine heptyl ester, creatine ethyl ester, creatinol-O-Phosphate, and a salt or a solvate thereof.

14. The method of claim 13, wherein the nutritional composition further comprises at least one of a component selected from the group consisting of heptanol, heptaminol, L-lyxoflavin, Oxytropis muricata, hydroxyphenethylamine, N-benzoyl-2-hydroxyphenethylamine, N-nicotinoyl-2-hydroxyphenethylamine, Echeveria glauca, Rhodiola rosea, Panax gingseng, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid, alpha-hydroxy-beta-methyl valeric acid, alpha-hydroxy-gamma-methylthiobutyric acid, alpha-hydroxy-beta-phenylpropionic acid, alpha-hydroxy-beta-imidazolepropionic acid, alpha-hydroxy-beta-hydroxybutyric acid, alpha-hydroxy-gamma-aminocaproic acid, alpha-hydroxy-gamma-guanidinovaleric acid, kamferol-3,7-dirhamnoside, Shilajit moomiyo extract, Kudzu (Pueraria lobata), Hawthorn (Crataegus monogyna), Loquat leaf extract, and mixtures thereof.

15. The method of claim 8, wherein the increased anabolism is increased muscle growth.

16. A method for enhancing physical performance or recovery, the method comprising administering to the subject an effective amount of a nutritional composition comprising at least one PPAR agonist, at least one PGC-1alpha agonist, at least one creatine derivative, and a nutraceutically acceptable carrier.

17. The method of claim 16, further comprising administering the nutritional composition before, during, or after exercise.

18. The method of claim 16, wherein the PPAR is PPAR-alpha.

19. The method of claim 18, wherein the at least one PPAR-alpha agonist is selected from one or more of the group consisting of Epimedium sagittatum, Epimedium grandiflorum, and sodium pyruvate.

20. The method of claim 18, wherein the at least one PGC-1alpha agonist is selected from the group consisting of Epimedium sagittatum, Epimedium grandiflorum, sodium pyruvate, piceatannol, Rhodiola rosea, and Japanese Knotweed.

21. The method of claim 17, wherein the creatine derivative is selected from the group consisting of creatine, creatine heptyl ester, creatine ethyl ester, creatinol-O-Phosphate, and a salt or a solvate thereof.

22. The method of claim 21, wherein the nutritional composition further comprises at least one of a component selected from the group consisting of heptanol, heptaminol, L-lyxoflavin, Oxytropis muricata, hydroxyphenethylamine, N-benzoyl-2-hydroxyphenethylamine, N-nicotinoyl-2-hydroxyphenethylamine, Echeveria glauca, Rhodiola rosea, Panax gingseng, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid, alpha-hydroxy-beta-methyl valeric acid, alpha-hydroxy-gamma-methylthiobutyric acid, alpha-hydroxy-beta-phenylpropionic acid, alpha-hydroxy-beta-imidazolepropionic acid, alpha-hydroxy-beta-hydroxybutyric acid, alpha-hydroxy-gamma-aminocaproic acid, alpha-hydroxy-gamma-guanidinovaleric acid, kamferol-3,7-dirhamnoside, Shilajit moomiyo extract, Kudzu (Pueraria lobata), Hawthorn (Crataegus monogyna), Loquat leaf extract, and mixtures thereof.

23. The method of claim 17, wherein said method increases total work output.

24. The method of claim 17, wherein said method increases muscle growth.