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RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF

  • US 20110111491A1
  • Filed: 05/05/2010
  • Published: 05/12/2011
  • Est. Priority Date: 08/05/2002
  • Status: Active Grant
First Claim
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1. An RNA duplex comprising a first strand of RNA and a second strand of RNA, wherein the first strand comprises at least 15 contiguous nucleotides encoded by(a) shHDEx2.1 (SEQ ID NO:

  • 7),(b) shHDEx2.2 19 nt (SEQ ID NO;

    8),(c) shHDEx2.2 21 nt (SEQ ID NO;

    9),(d) shHDEx3.1 19 nt (SEQ ID NO;

    10),(e) shHDEx3.1 21 nt (SEQ ID NO;

    11),(f) siEX58#1 (SEQ ID NO;

    12),(g) siEX58#2 (SEQ ID NO;

    17),(h) shSCA1.F10 (SEQ ID NO;

    13), or(i) shSCA1.F11 (SEQ ID NO;

    14),and wherein the second strand is complementary to at least 12 contiguous nucleotides of the first strand.

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