NEONATAL SALIVARY GENOMICS
First Claim
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1. A method for detecting or identifying genes involved in a condition or disease affecting neonates comprising steps of:
- providing a test sample of saliva RNA obtained from a neonate suffering from or diagnosed with a condition;
subjecting the test sample of saliva RNA to an analysis, wherein the analysis comprises hybridizing the RNA to one or more oligonucleotide probes, such that one or more genes that are differentially regulated in the sample as compared to a control sample is/are identified, wherein the control sample comprises saliva RNA obtained from a neonate that is not suffering from or diagnosed with the condition; and
determining that the one or more differentially regulated genes are involved in the condition or disease.
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Abstract
The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or conditions affecting neonates, are provided. Methods of determining a diagnosis of a neonate comprising detection of one or more differentially expressed genes are also provided.
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Citations
18 Claims
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1. A method for detecting or identifying genes involved in a condition or disease affecting neonates comprising steps of:
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providing a test sample of saliva RNA obtained from a neonate suffering from or diagnosed with a condition; subjecting the test sample of saliva RNA to an analysis, wherein the analysis comprises hybridizing the RNA to one or more oligonucleotide probes, such that one or more genes that are differentially regulated in the sample as compared to a control sample is/are identified, wherein the control sample comprises saliva RNA obtained from a neonate that is not suffering from or diagnosed with the condition; and determining that the one or more differentially regulated genes are involved in the condition or disease. - View Dependent Claims (2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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4. A method for detecting or identifying genes involved in neonatal development comprising steps of:
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providing a test sample of saliva RNA obtained from a neonate; subjecting the test sample of saliva RNA to an analysis, wherein the analysis comprises hybridizing the RNA to one or more oligonucleotide probes, such that one or more genes that are differentially regulated in the sample as compared to a control sample is/are detected or identified, wherein the control sample comprises saliva RNA obtained from a neonate at a developmental stage different than the neonate from which the test sample of saliva RNA sample was obtained; and determining that the one or more differentially regulated genes are involved in neonatal development. - View Dependent Claims (5, 6)
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Specification