Systems and Methods for Diagnostics, Control and Treatment of Neurological Functions and Disorders by Exposure to Electromagnetic Waves

• US 20110118556A1
• Filed: 11/12/2010
• Published: 05/19/2011
• Est. Priority Date: 11/13/2009
• Status: Abandoned Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Siegel, Peter H., Pikov, Victor
• Application Number:
  US12/945,553
• Publication Number:
  US 20110118556A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 5/02 using microwaves

Abstract

Methods, systems and devices are provided in which electromagnetic waves (EMWs) are applied to a neural target. The neuronal function of at least a portion of the neural target is monitored, and the effect of EMW application on neural properties, neural function, and/or neural disorders is assessed. Embodiments include methods of diagnosis, treatment, drug delivery, cognitive enhancement, and EMW stimulation systems.

Claims

1. A method of diagnosing a neural disorder, comprising:

applying electromagnetic waves (EMWs) at a frequency in the range of 3 to 300 GHz to a neural target of a subject so as to alter a neural property of the target,

comparing the neural property of the target after EMW application to the same neural property of a similarly treated control target, and

diagnosing a neural disorder in the subject when a difference in the neural properties is observed.

2. The method of claim 1, further comprising discontinuing the EMW application in the event that the EMWs are applied in a manner that exceeds a predetermined upper EMW application limit.

3. The method of claim 1, wherein the applying of the EMWs comprises applying several EMW amplitudes or applying in a duty cycled manner.

4. The method of claim 1, wherein the neural target is selected from the group consisting of cerebral cortex, deep brain, brainstem, spinal cord, optic tract, optic nerve, retina, cranial nerves, spinal roots, peripheral nerves, and nerve endings in the skin, and a combination thereof.

5. A method of treating a neural disorder, comprising:

exposing a neural target of a subject in need of such treatment to electromagnetic waves (EMWs) at a frequency in the range of 3 to 300 GHz in an amount sufficient to alter a neural property of the neural target, thereby conferring a therapeutic benefit on the subject, wherein the neural target is identified with a neural disorder.

6. The method of claim 5, further comprising discontinuing the EMW exposure in the event that the EMWs are applied in a manner that exceeds a predetermined upper EMW exposure limit.

7. The method of claim 5, wherein the exposing of the neural target comprises exposing the neural target to several EMW amplitudes or to EMWs in a duty cycled manner.

8. The method of claim 5, further comprising monitoring neuronal function of the subject.

9. The method of claim 5, wherein the neural target is selected from the group consisting of cerebral cortex, deep brain, brainstem, spinal cord, optic tract, optic nerve, retina, cranial nerves, spinal roots, peripheral nerves, and nerve endings in the skin, and a combination thereof.

10. A method of delivering a drug, comprising:

exposing a neural target in a subject'"'"'s central nervous system or optic system to electromagnetic waves (EMWs) at a frequency in the range of 3 to 300 GHz in an amount sufficient to alter the subject'"'"'s blood-brain or blood-retinal barrier, respectively, and

administering a drug to the subject before, during, or after the EMW exposure, or any combination thereof, such that the drug crosses the blood-brain or blood-retinal barrier.

11. A method of cognitive enhancement, comprising

exposing a neural target in a subject'"'"'s central nervous system to electromagnetic waves (EMWs) at a frequency in the range of 3 to 300 GHz in an amount sufficient to alter a neural property of the neural target, thereby increasing cognitive ability in the subject.

12. An electromagnetic wave (EMW) stimulation system for a subject, comprising:

a housing that is implantable, portable, head-mountable, skin-mountable, or eye-mountable, or a combination thereof;

a control unit, for controlling production of EMWs;

at least one EMW source carried by the housing and operatively coupled to the control unit; and

an EMW delivery device comprising at least one emission site operatively coupled to the EMW source.

13. The system of claim 12, wherein the housing is constructed from flexible polymer substrate upon which the wave delivery device is positioned, the wave delivery device comprising metal traces for forming a surface waveguide and an output EMW shaping element coupled to the waveguide.

14. The system of claim 12, wherein the EMW delivery device comprises an elongate member and first and second EMW emission sites carried by the elongate member, wherein the first and second emission sites are separated along a length of the elongate member by a predetermined distance.

15. The system of claim 12, wherein the EMW delivery device comprises:

an elongate member that comprises a proximal segment and a distal segment, where the segments have different geometric shapes; and

a first wave emission site carried by the elongate member.

16. The system of claim 12, further comprising a unit for monitoring neuronal function operatively coupled to the control unit.

17. The system of claim 12, wherein the control unit is carried by the housing.