Targeted Inhibition of Physiologic and Pathologic Processes
First Claim
Patent Images
1. A method of inhibiting the function of a nerve traveling with an artery comprising:
- providing an external imaging modality to determine the location of the artery of a patient;
placing the artery in a first three dimensional coordinate reference based on the imaging;
placing or associating a therapeutic energy generation source in the first three dimensional coordinate reference frame;
modeling the delivery of energy to the adventitial region of the artery or a region adjacent to the artery where a nerve travels;
delivering therapeutic energy from the therapeutic energy source, from at least two different angles, through the skin of a patient, to intersect at the artery or the region adjacent to the artery;
and, at least partially inhibiting the function of the nerve traveling with the artery.
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Abstract
In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
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Citations
19 Claims
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1. A method of inhibiting the function of a nerve traveling with an artery comprising:
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providing an external imaging modality to determine the location of the artery of a patient; placing the artery in a first three dimensional coordinate reference based on the imaging; placing or associating a therapeutic energy generation source in the first three dimensional coordinate reference frame; modeling the delivery of energy to the adventitial region of the artery or a region adjacent to the artery where a nerve travels; delivering therapeutic energy from the therapeutic energy source, from at least two different angles, through the skin of a patient, to intersect at the artery or the region adjacent to the artery; and, at least partially inhibiting the function of the nerve traveling with the artery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system to inhibit the function of a nerve traveling with a renal artery comprising:
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a detector to determine the location of the renal artery and renal nerve from a position external to a patient; an ultrasound component to deliver therapeutic energy through the skin from at least two directions to the nerve surrounding the renal artery; a modeling algorithm comprising an input and an output, said input to the modeling algorithm comprising a three dimensional coordinate space containing a therapeutic energy source and the position of the renal artery in the three dimensional coordinate space; and
,said output from the modeling algorithm comprising;
the direction and energy level of the ultrasound component;a fiducial, locatable from a position outside a patient, adapted to be temporarily placed in the artery of the patient and communicate with the detector to determine the location of the renal artery in a three dimensional reference frame, the information regarding the location transmittable as the input to the model. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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Specification