EXTRACORPOREAL BLOOD TREATMENT APPARATUS

• US 20110118647A1
• Filed: 07/03/2009
• Published: 05/19/2011
• Est. Priority Date: 07/09/2008
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Paolini, Francesco, Grandi, Fabio, Fontanazzi, Francesco
• Granted Patent: US 8,684,959 B2
• Time in Patent Office: Days
• US Class Current: 604/6.09
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1647 with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
• CPC Class Codes: A61M 1/361 before treatment

Abstract

An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual'"'"'s weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.

Claims

1-14. -14. (canceled)

15. An extracorporeal blood treatment apparatus, comprising:

a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane;

an extracorporeal blood circuit connected to the blood chamber for transporting blood from an individual to the blood chamber and for returning the blood from the blood chamber to the individual;

a sensor predisposed in the extracorporeal blood circuit for emitting at least a signal indicating a variation in hematic volume of the individual subjected to extracorporeal blood treatment;

a weight loss system for actuating an individual'"'"'s weight loss during the extracorporeal blood treatment;

a control unit configured for performing following operations;

receiving an effective weight value of the individual;

receiving a desired weight loss value of the individual;

determining at least a desired value of a hematic volume change of the individual on a basis of the effective weight value and the desired weight loss value, wherein the operation of determining at least a desired value of a hematic volume change comprises sub-operations of;

receiving a desired value of a second parameter of the individual;

calculating a desired value of the individual'"'"'s parameter on a basis of the desired value of the individual'"'"'s second parameter, the effective weight value and the desired value of the weight loss by calculating a relative hematic volume change on a basis of the desired value of the individual'"'"'s using formula;

Δ

BV%=RI*WL%

where Δ

BV% is the variation in relative hematic volume, i.e. the variation of hematic volume in relation to the total hematic volume, RI is the desired value of the individual'"'"'s second parameter and WL% is the relative weight loss where the relative weight loss is calculated on a basis of a relation between the desired weight loss and the effective weight of the patient;

controlling the weight loss system on a basis of the signal of hematic volume change and the desired value of a parameter of the individual.

16. The apparatus of claim 15, wherein the control unit is configured for determining a plurality of desired values of the individual'"'"'s parameter according to a treatment time on a basis of the at least a desired value of the individual'"'"'s parameter.

17. The apparatus of claim 15, wherein the desired value of an individual'"'"'s parameter comprises an objective value which it is desired to obtain at end of treatment.

18. The apparatus of claim 15, wherein the control unit is configured to receive a minimum and a maximum threshold value of acceptability for the individual'"'"'s second parameter.

19. The apparatus of of claim 15, wherein the control unit is configured for receiving a range of acceptability for the individual'"'"'s second parameter.

20. The apparatus of claim 19, wherein the range of acceptability is comprised between 0.5 and 2.0.

21. The apparatus of claim 15, wherein the individual'"'"'s effective weight loss value comprises a value selected from between the total body weight of the individual before or after the treatment and the weight of the individual'"'"'s bodily water before or after the treatment.

22. The apparatus of claim 15, wherein the weight loss system comprises an ultrafiltration device for liquid ultra-filtration from the blood chamber to the fluid chamber through the semipermeable membrane, the control unit being configured for controlling the ultrafiltration device on a basis of the hematic volume change signal and the desired value of a parameter of the individual.

23. The apparatus of claim 15, wherein the weight loss system comprises an infusion device for infusing a liquid into the extracorporeal circuit, the control unit being configured for controlling the infusion device on a basis of the hematic volume change signal and the desired value of a parameter of the individual.

24. The apparatus of claim 15, comprising a supply system for supplying a treatment fluid of a predetermined composition to the fluid chamber, the control unit being configured for controlling the supply system on a basis of the hematic volume change signal and the desired value of a parameter of the individual.

25. An extracorporeal blood treatment apparatus, comprising:

a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane;

an extracorporeal blood circuit connected to the blood chamber for transporting blood from an individual to the blood chamber and for returning the blood from the blood chamber to the individual;

a sensor predisposed in the extracorporeal blood circuit for emitting at least a signal indicating a variation in hematic volume of the individual subjected to extracorporeal blood treatment;

a weight loss system for actuating an individual'"'"'s weight loss during the extracorporeal blood treatment;

a control unit configured for performing following operations;

receiving an effective weight value of the individual;

receiving a desired weight loss value of the individual;

determining at least a desired value of a hematic volume change of the individual on a basis of the effective weight value and the desired weight loss value, wherein the operation of determining at least a desired value of a hematic volume change comprises sub-operations of;

receiving a desired value of a second parameter of the individual;

calculating a desired value of the hematic volume change on a basis of the desired value of the individual'"'"'s second parameter, the effective weight value and the desired value of the weight loss by calculating a relative hematic volume change on a basis of the desired value of the individual'"'"'s second parameter and a relative weight loss, where the relative weight loss is calculated on a basis of a relation between the desired weight loss and the effective weight of the patient;

controlling the weight loss system on a basis of the signal of hematic volume change and the desired value of a parameter of the individual.

26. An extracorporeal blood treatment apparatus, comprising:

a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane;

an extracorporeal blood circuit connected to the blood chamber for transporting blood from an individual to the blood chamber and for returning the blood from the blood chamber to the individual;

a sensor predisposed in the extracorporeal blood circuit for emitting at least a signal indicating a variation in hematic volume of the individual subjected to extracorporeal blood treatment;

a weight loss system for actuating an individual'"'"'s weight loss during the extracorporeal blood treatment;

a control unit configured for performing following operations;

receiving an effective weight value of the individual;

receiving a desired weight loss value of the individual;

determining at least a desired value of a hematic volume change of the individual on a basis of the effective weight value and the desired weight loss value,

controlling the weight loss system on a basis of the signal of hematic volume change and the desired value of a parameter of the individual.

27. The apparatus of claim 26, wherein the operation of determining at least a desired value of an individual'"'"'s parameter comprises sub-operations of:

receiving a desired value of a second parameter of the individual;

calculating a desired value of the individual'"'"'s parameter on a basis of the desired value of the individual'"'"'s second parameter, the effective weight value and the desired value of the weight loss.

28. The apparatus of claim 26, wherein calculating the desired value of the individual'"'"'s parameter comprises calculating a relative hematic volume change on a basis of the desired value of the individual'"'"'s second parameter and a relative weight loss, where the relative weight loss is calculated on a basis of a relation between the desired weight loss and the effective weight of the patient.

29. The apparatus of claim 28, wherein the relative variation in hematic volume is calculated using formula as follows:

Δ

BV%=RI*WL%

where Δ

BV% is the variation in relative hematic volume, i.e. the variation of hematic volume in relation to the total hematic volume, RI is the desired value of the individual'"'"'s second parameter and WL% is the relative weight loss, i.e. the weight loss in relation to the individual'"'"'s effective weight.