ENCAPSULATED OR COATED STENT SYSTEMS

• US 20110118818A1
• Filed: 06/17/2005
• Published: 05/19/2011
• Est. Priority Date: 06/17/2003
• Status: Abandoned Application

• Current Assignee: Gel-Del Technologies, Inc. (PetVivo Holdings, Inc.)
• Original Assignee: Gel-Del Technologies, Inc. (PetVivo Holdings, Inc.)
• Inventors: Masters, David B., Berg, Eric P.
• Application Number:
  US11/916,165
• Publication Number:
  US 20110118818A1
• Time in Patent Office: Days
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/064 with special features to facilitate anastomotic coupling anastomosis of natural blood vessels A61B17/11
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2250/0063 Nested prosthetic parts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

A stent system comprising zero or more inner stents inserted into an outer stent. The inner stents and outer stent are separated and/or encapsulated by a protein-based material of a protein matrix and/or a set biocoacervate, each comprising one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.

Claims

1. A stent system comprising:

two or more metallic or polymeric stents that are fitted to be inserted into each other; and

a protein based material coating or encapsulating the one or more of the metallic or polymeric stents, the protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.

2. The stent system of claim 1 wherein the protein based material is a protein matrix material or a biocoacervate material.

3. The stent system of claim 2 wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

4. The stent system of claim 1 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

5. The stent system of claim 1 wherein the biocompatible solvent is water.

6. The stent system of claim 1 further comprising one or more pharmacologically active agents.

7. The stent system of claim 6 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

8. A single strand stent system comprising a single strand twisted to form a loop strut or two or more rounded loops said loop strut or loops coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.

9. The single strand stent system of claim 8 wherein the protein based material is a protein matrix material or a biocoacervate material.

10. The single strand stent system of claim 9 wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

11. The single strand stent system of claim 8 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

12. The single strand stent system of claim 8 wherein the biocompatible solvent is water.

13. The single strand stent system of claim 8 further comprising one or more pharmacologically active agents.

14. The single strand stent system of claim 13 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

15. The single strand stent system of claim 8 further comprising a mesh tube coated or encapsulated with the protein based material.

16. The single strand stent system of claim 8 includes the two or more loops and the loops are selected from the group consisting of o-rings, c-rings and oval-rings.

17. A graft fastener comprising two or more clamping devices adjoined by a linking member and coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.

18. The graft fastener of claim 17 wherein the protein based material is a protein matrix material or a biocoacervate material.

19. The graft fastener of claim 18 wherein the graft fastener is coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

20. The graft fastener of claim 17 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

21. The graft fastener of claim 17 wherein the biocompatible solvent is water.

22. The graft fastener of claim 17 further comprising one or more pharmacologically active agents.

23. The graft fastener of claim 22 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

24. The graft fastener of claim 17 wherein the clamping devices are selected from the group consisting of o-rings, c-rings and oval-rings.

25. The graft fastener of claim 17 wherein the clamping devices are adjoined with a linking member.

26. A method of repairing a damaged or diseased vessel comprising:

providing a stent system including two or more metallic or polymeric stents that are fitted to be inserted into each other; and

a protein based material coating or encapsulating the one or more of the metallic or polymeric stents, the protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents;

administering the stent system to a damaged or diseased vessel.

27. The method of repairing a damaged or diseased vessel of claim 26 wherein the protein based material is a protein matrix material or a biocoacervate material.

28. The method of repairing a damaged or diseased vessel of claim 27 wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

29. The method of repairing a damaged or diseased vessel of claim 26 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

30. The method of repairing a damaged or diseased vessel of claim 26 wherein the biocompatible solvent is water.

31. The method of repairing a damaged or diseased vessel of claim 26 further comprising one or more pharmacologically active agents.

32. The method of repairing a damaged or diseased vessel of claim 26 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

33. A method of repairing a damaged or diseased vessel comprising:

providing a single strand stent system comprising a single strand twisted to form a loop strut or two or more rounded loops said loop strut or loops coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents; and

administering the single strand stent system to a damaged or diseased vessel.

34. The method of repairing a damaged or diseased vessel of claim 33 wherein the protein based material is a protein matrix material or a biocoacervate material.

35. The method of repairing a damaged or diseased vessel of claim 34 wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

36. The method of repairing a damaged or diseased vessel of claim 33 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

37. The method of repairing a damaged or diseased vessel of claim 33 wherein the biocompatible solvent is water.

38. The method of repairing a damaged or diseased vessel of claim 33 further comprising one or more pharmacologically active agents.

39. The method of repairing a damaged or diseased vessel of claim 38 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

40. The method of repairing a damaged or diseased vessel of claim 33 further comprising a mesh tube coated or encapsulated with the protein based material.

41. The method of repairing a damaged or diseased vessel of claim 33 includes the two or more loops and the loops are selected from the group consisting of o-rings, c-rings and oval-rings.

42. A method of securing a vessel graft, stent or stent system in a vessel comprising,

positioning a vessel graft, stent or stent system in a vessel lumen;

placing a graft fastener over the outer surface of the vessel and securing in place the vessel graft stent, or stent system, wherein the graft fastener includes two or more clamping devices adjoined by a linking member and coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.

43. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 wherein the protein based material is a protein matrix material or a biocoacervate material.

45. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin.

46. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 wherein the biocompatible solvent is water.

47. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 further comprising one or more pharmacologically active agents.

48. The method of securing a vessel graft, stent or stent system in a vessel of claim 46 wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol.

49. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 wherein the clamping devices are selected from the group consisting of o-rings, c-rings and oval-rings.

50. The method of securing a vessel graft, stent or stent system in a vessel of claim 42 wherein the clamping devices are adjoined with a linking member.

44. The method of securing a vessel graft, stent or stent system in a vessel of claim 44 wherein the graft fastener is coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.