Reperfusion Protection in Resuscitation

• US 20110120471A1
• Filed: 02/03/2011
• Published: 05/26/2011
• Est. Priority Date: 01/24/2006
• Status: Active Grant

• Current Assignee: Zoll Medical Corporation (Asahi Kasei Corporation)
• Original Assignee: Zoll Medical Corporation (Asahi Kasei Corporation)
• Inventors: Freeman, Gary A.
• Granted Patent: US 9,457,165 B2
• Time in Patent Office: Days
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/0081 Bag or bellow in a bottle
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 2016/0413 with detectors of CO2 in exhaled gases
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0225 Carbon oxides, e.g. Carbon dioxide
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/202 partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
• CPC Class Codes: A61M 2230/208 pH-value
• CPC Class Codes: A61M 2230/40 Respiratory characteristics

Abstract

An apparatus and method for resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted. A ventilator is used for delivering a gas mixture to the patient. The ventilator is configured to adjust the partial pressure of CO2 to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain a reduced pH in the patient'"'"'s tissues for a period of time following return of spontaneous circulation.

Claims

1. A method of resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted, the method comprising:

applying a ventilator to the patient;

delivering a gas mixture to the patient using the ventilator,

wherein the ventilator is configured to adjust the partial pressure of CO₂ to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain a reduced pH in the patient'"'"'s tissues for a period of time following return of spontaneous circulation.

2. The method of claim 1 wherein the partial pressure of CO₂ is adjusted to be higher than ambient CO₂ partial pressure during the period of time.

3. The method of claim 1 wherein adjustment of the partial pressure of CO₂ includes adding CO₂ to the gas inspired by the patient.

4. The method of claim 1 further comprising providing a sensor and associated processing for measuring a physiological status of the patient, wherein the partial pressure of CO₂ is adjusted at least in part in response to the output of the sensor.

5. The method of claim 4 wherein the sensor and associated processing are configured to detect return of spontaneous circulation, and wherein the partial pressure of CO₂ is changed in response to detection of return of spontaneous circulation.

6. The method of claim 1 wherein adjustment of the partial pressure of CO₂ has the effect of maintaining the pH of the patient'"'"'s tissues below 7.0 for the period of time following return of spontaneous circulation.

7. The method of claim 1 further comprising using a sensor and associated processing for determining the pH of the patient'"'"'s tissue, and adjusting the partial pressure of CO₂ at least in part in response to the pH of the patient'"'"'s tissue.

8. The method of claim 1 wherein the period of time begins prior to the return of spontaneous circulation.