SELF-FIXATING SCAFFOLDS

• US 20110123593A1
• Filed: 01/18/2011
• Published: 05/26/2011
• Est. Priority Date: 10/14/2005
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sigg, Daniel C., Hiniduma-Lokuge, Prasanga D., Sommer, John L., Sharma, Vinod
• Application Number:
  US13/008,501
• Publication Number:
  US 20110123593A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.

Claims

1. A self-fixating scaffold device comprising:

a scaffold fabricated of a porous polymeric material and holding a therapeutic material; and

a skeleton removably implanted within the scaffold;

wherein the scaffold changes form upon removal of the skeleton to anchor the scaffold in tissue.

2. The self-fixating scaffold device of claim 1, wherein the skeleton is fabricated from a metallic material.

3. The self-fixating scaffold device of claim 1, wherein the therapeutic material is impregnated into the scaffold prior to delivery to the tissue.

4. The self-fixating scaffold device of claim 1, wherein the skeleton comprises a lead for remote control implantation.

5. A self-fixating scaffold device for location in tissue, comprising:

a scaffold holding a therapeutic material, wherein the scaffold comprises a body formed of a porous polymeric material; and

a skeleton removably implanted within the scaffold, wherein the skeleton is removably implanted within the material forming the body of the scaffold;

wherein the skeleton constrains the scaffold in a first configuration and wherein upon removal of the skeleton the scaffold assumes a second configuration to anchor the scaffold in the tissue.

6. The self-fixating device of claim 5, wherein the scaffold in the first configuration exhibits a first dimension across the scaffold and wherein the scaffold in the second configuration exhibits a second, greater dimension across the scaffold.

7. The self-fixating device of claim 5, wherein upon removal of the skeleton, the scaffold expands.

8. The self-fixating device of claim 5, wherein the scaffold is biodegradable.

9. The self fixating device of claim 5, wherein the scaffold is fabricated from at least one of:

PLA, PGA, PLGA, PEG, PCL, PLLA, polyurethane-PCL, polyurethane-PEO, PCLA, alginate, collagen, starch/cellulose, cellulose acetate, fibrin, platelet gel, hydrogel, gelatin, chitin, pectin, and hyaluronic acid.

10. The self-fixating device of claim 5, wherein the therapeutic material is biological material.

11. The self-fixating device of claim 10, wherein the biological material is adapted to treat at least one of the following conditions:

cardiac dysfunctions, neurological dysfunctions, endocrinological dysfunctions, diseased or damaged tissues, and cancer.

12. The self-fixating device of claim 10, wherein the biological material is present in the scaffold before the scaffold is anchored in the tissue.

13. The self-fixating device of claim 5, wherein the tissue comprises myocardial tissue.

14. The self-fixating device of claim 5, wherein the therapeutic material is a pharmaceutical drug.

15. The self-fixating device of claim 5 wherein the drug is present in the scaffold before the scaffold is anchored in the tissue.

16. The self-fixating device of claim 5 wherein the skeleton is fabricated from a metallic material.

17. The self-fixating device of claim 5, wherein the scaffold has a lattice structure for accomplishing directed cell growth.

18. The self-fixating device of claim 17, wherein the scaffold has pores of between about 30 micrometers and 120 micrometers in diameter.

19. The self-fixating device of claim 5, wherein the scaffold comprises fixation elements and wherein in the first configuration, the fixation elements have a first position and wherein in the second configuration the fixation elements have a second position.

20. A self-fixating device of claim 19 wherein the fixation elements comprise arms and wherein in the second configuration the arms are opened.