ANTIMICROBIAL POLYMERS AND THEIR USES
First Claim
1. An antimicrobially active polymer molecule having the formula P-(L-R-S)n wherein the moiety -(L-R-S)n is an endgroup on said polymer molecule and the variable n is an integer of 1 to 2 in a linear polymer and is an integer of 3 to 100 in a branched or dendrite polymer, in which:
- P represents a polymer moiety having a number average molecular weight of 5000 to 1,000,000, and selected from the group consisting of polyurethanes, polysiloxanes, polyamides, polyimides, polyethers, polyesters, polycarbonates, polyolefins, polysulfones, and copolymers thereof;
L represents an aliphatic or aromatic linkage having a number average molecular weight of up to about 1000, covalently linking the moiety R to the moiety P;
R represents an antimicrobially active organic or organometallic moiety; and
S represents a surface active endgroup having a number average molecular weight of up to 1000 and selected from the group consisting of straight, branched, or cyclic alkyl groups having 4 to 22 carbon atoms, polyalkylene oxides, fluorinated polyalkylene oxides, polysiloxanes, fluorinated polysiloxanes, polysiloxane polyethers, and mixtures thereof,wherein the moiety -(L-R-S)n moves to surface of an article made from a plurality of said polymer molecules during or after fabrication of the article, thereby providing a polymeric article in which the surface has antimicrobial properties.
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Accused Products
Abstract
Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
32 Citations
19 Claims
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1. An antimicrobially active polymer molecule having the formula P-(L-R-S)n wherein the moiety -(L-R-S)n is an endgroup on said polymer molecule and the variable n is an integer of 1 to 2 in a linear polymer and is an integer of 3 to 100 in a branched or dendrite polymer, in which:
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P represents a polymer moiety having a number average molecular weight of 5000 to 1,000,000, and selected from the group consisting of polyurethanes, polysiloxanes, polyamides, polyimides, polyethers, polyesters, polycarbonates, polyolefins, polysulfones, and copolymers thereof; L represents an aliphatic or aromatic linkage having a number average molecular weight of up to about 1000, covalently linking the moiety R to the moiety P; R represents an antimicrobially active organic or organometallic moiety; and S represents a surface active endgroup having a number average molecular weight of up to 1000 and selected from the group consisting of straight, branched, or cyclic alkyl groups having 4 to 22 carbon atoms, polyalkylene oxides, fluorinated polyalkylene oxides, polysiloxanes, fluorinated polysiloxanes, polysiloxane polyethers, and mixtures thereof, wherein the moiety -(L-R-S)n moves to surface of an article made from a plurality of said polymer molecules during or after fabrication of the article, thereby providing a polymeric article in which the surface has antimicrobial properties. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19-20. -20. (canceled)
Specification