RADIOLABELED TREATMENT INFUSION SYSTEM, APPARATUS, AND METHODS OF USING THE SAME
First Claim
1. A shielded enclosure suitable for reducing radiation exposure during infusion of a radioactive substance comprising:
- a radiation shield defining a shielded cavity suitable for storing a vial containing at least one dose of a radioactive substance, the radiation shield further defining a first aperture providing external access to the shielded cavity and a second aperture suitable for transferring the vial into and out of the shielded cavity;
a shielded plug removably attachable to the radiation shield and adapted to shield the first aperture when attached thereto; and
a shielded panel removably attachable to the radiation shield and adapted to shield the second aperture when attached thereto, the radiation shield together with the shielded plug and the shielded panel when attached, forming a substantially continuous shielded cavity, the radiation shielding suitable for reducing radiation exposure during infusion of the radioactive substance from the vial to a patient.
3 Assignments
0 Petitions
Accused Products
Abstract
Described herein are methods and devices for infusion of a radioactive compound, such as yttrium-90 radiolabeled somatostatin peptide or analog. A radiation shield defining a shielded cavity suitable for storing a radioactive substance includes a first aperture providing external access to the shielded cavity and a second aperture suitable for transferring a dosage vial into and out of the shielded cavity. A removable shielded plug and panel are adapted to shield respective apertures of the radiation shield. At least one dose of a radiolabeled compound stored in a vial in the radiation shield is delivered through a fluid communication channel at a rate of about 500 mL/hour. The fluid communication channel is washed after delivery, such that the process substantially reduces radiation exposure during infusion of the radiolabeled compound into a patient.
24 Citations
24 Claims
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1. A shielded enclosure suitable for reducing radiation exposure during infusion of a radioactive substance comprising:
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a radiation shield defining a shielded cavity suitable for storing a vial containing at least one dose of a radioactive substance, the radiation shield further defining a first aperture providing external access to the shielded cavity and a second aperture suitable for transferring the vial into and out of the shielded cavity; a shielded plug removably attachable to the radiation shield and adapted to shield the first aperture when attached thereto; and a shielded panel removably attachable to the radiation shield and adapted to shield the second aperture when attached thereto, the radiation shield together with the shielded plug and the shielded panel when attached, forming a substantially continuous shielded cavity, the radiation shielding suitable for reducing radiation exposure during infusion of the radioactive substance from the vial to a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of administering a radiolabeled compound to a patient comprising:
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placing a reservoir containing at least one dose of a radioactive compound in a shielded enclosure having a fluid access port; providing a fluid communication channel between the reservoir and a patient; delivering at least one dose of the radiolabeled compound through the fluid communication channel at a rate of about 500 mL/hour; and washing the fluid communication channel after delivery of the radiolabeled compound, wherein radiation exposure during infusion of the radiolabeled compound into a patient is substantially reduced. - View Dependent Claims (10, 11, 12, 13, 14)
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15. An intravenous injection apparatus comprising:
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a first reservoir storing a first non-radioactive compound; a first fluid line in fluid communication between the first reservoir and a patient-side needle; a second reservoir storing a saline solution; a second fluid line in fluid communication with the patient-side needle; and a vial shield surrounding a vial containing a radioactive compound, the vial in fluid communication with the second fluid line, the apparatus operable to inject a dose of radioactive compound into a living subject operably coupled to the second end of the fluid line. - View Dependent Claims (16, 17, 18, 19)
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20. A method for reducing radiation exposure during infusion of a radioactive compound into a patient comprising:
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storing a vial containing at least one dose of a radioactive compound in a shielded enclosure having an aperture blocked by a shielded access plug; removing the shielded access plug from shielded enclosure thereby exposing the aperture; coupling an intravenous (IV) fluid line between the vial containing the at least one dose of a radioactive compound and the patient, the coupling occurring through the exposed aperture; infusing at least a portion of the at least one dose of a radioactive compound into the patient through the IV fluid line. - View Dependent Claims (21, 22, 23, 24)
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Specification