METHOD FOR ASSESSING BRAIN FUNCTION AND PORTABLE AUTOMATIC BRAIN FUNCTION ASSESSMENT APPARATUS

• US 20110125048A1
• Filed: 02/01/2011
• Published: 05/26/2011
• Est. Priority Date: 08/02/2005
• Status: Active Grant

• Current Assignee: Brainscope SPV LLC
• Original Assignee: Brainscope Company Inc.
• Inventors: Causevic, Elvir Causevic, Combs, Arthur H.
• Granted Patent: US 8,838,227 B2
• Time in Patent Office: Days
• US Class Current: 600/544
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A method and apparatus for performing rapid brain assessment may provide emergency triage to head trauma patients by analyzing a combination of spontaneous and evoked brain potentials. The spontaneous and evoked potentials are analyzed, and the results classified, to present a real-time assessment of a patient'"'"'s brain, diagnosing any potential abnormalities therein.

Claims

1-27. -27. (canceled)

28. An apparatus for determining the neurological state of a subject, comprising:

a processor;

a memory operatively coupled to the processor, wherein

the memory stores one or more operating instructions;

an input-output interface having at least one channel operatively coupled to the processor, wherein

the input-output interface is configured to receive external brain electrical signals through a set of electrodes placed on the subject; and

the processor is configured to utilize the one or more operating instructions to perform one or more operations on the signals received from the input-output interface, wherein the one or more operations comprise;

de-noising the received signals;

extracting features from the de-noised signals;

classifying the extracted features; and

determining a neurological state of the subject based on the classification,

wherein determining the neurological state comprises the steps of;

determining if the neurological state is normal or abnormal; and

determining if an abnormal neurological state is psychiatric or “

functional”

in nature, organic in nature, or an emergency or “

Alert”

condition.

29. The apparatus of claim 28, further comprising:

a display device, wherein

the display device is operatively connected to the processor and the processor is further configured to display results of the one or more operations on the display device.

30. The apparatus of claim 28, further comprising:

a bi-directional communications channel operatively connected to the input-output interface and to the processor to communicate the received signals.

31. The apparatus of claim 28, further comprising:

a low voltage preamplifier having at least one channel operatively connected to the input-output interface.

32. The apparatus of claim 31, wherein

the low voltage preamplifier has a high noise tolerance.

33. The apparatus of claim 28, wherein the input-output interface includes an electroencephalograph testing interface and an auditory evoked potentials testing interface;

and

wherein the processor is configured with the one or more stored operating instructions for auditory tests selected from the group comprising electroencephalograph test procedures, auditory evoked potentials test procedures, and combinations thereof.

34. The apparatus of claim 28, wherein

the processor has an internal memory, and the processor is configured to utilize the internal memory to execute one or more operating instructions for processing the received signals.

35. The apparatus of claim 28, wherein the extracted features are classified using discriminant analysis.

36. The apparatus of claim 28, wherein

the instructions for denoising the signals include instructions to filter the received signals.

37. The apparatus of claim 36, wherein the filtering comprises:

using a dual-tree complex wavelet transform of the received signals.

38. The apparatus of claim 28, wherein the set of electrodes comprises:

a plurality of electrodes placed on the subject'"'"'s forehead; and

at least one electrode placed in at least one of the ears of the subject.

39. The apparatus of claim 28, further comprising:

a stimulation device operatively connected to the input-output interface for evoking an auditory potential in the subject.

40. The apparatus of claim 28, wherein

the apparatus is housed in a hand-held enclosure.

41. The apparatus of claim 28, wherein the input-output interface further comprises:

a wireless input-output interface having at least one channel.

42. A kit for performing an emergency neurological diagnosis of a patient suffering from an altered mental state, the kit including:

the apparatus of claim 28;

instructions for using the apparatus; and

a portable carrying case for the apparatus.

43. An apparatus for providing an automatic brain function assessment comprising;

an electrode set;

a processor;

wherein

the electrode set and the processor are operatively connected through an input-output interface having at least one channel;

a display operatively connected to the processor;

a user interface operatively connected to the processor; and

internal memory, wherein

the memory contains instructions for providing a real-time assessment of a subject'"'"'s brain function; and

the memory contains instructions for processing signals acquired by the electrode set using wavelet-packet algorithms.

44-64. -64. (canceled)