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Production of an Organic Acid and/or Related Chemicals

  • US 20110125118A1
  • Filed: 11/22/2010
  • Published: 05/26/2011
  • Est. Priority Date: 11/20/2009
  • Status: Abandoned Application
First Claim
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1. A method for producing 3-hydroxypropionic acid (3-HP) comprising:

  • i) combining hydrogen, a carbon source selected from carbon monoxide and carbon dioxide, and a culture of microorganism cells, whereina) said microorganism cells are genetically transformed to introduce or increase one or more enzymatic activities for conversion of the carbon source to malonate semialdehyde, wherein said enzymatic activities are selected from the group consisting of phosphoglucose isomerase, inositol-1-phosphate synthase, inositol deoxy-D-gluconate isomerase, 5-dehydro-2-deoxygluconokinase, and deoxyphophogluconate aldolase; and

    b1) said microorganism cells are genetically transformed to introduce or increase enzymatic activity for conversion of malonate semialdehyde to 3-HP, and/orb2) said microorganism cells are capable of producing 3-HP at a rate of at least 1 g/L/hr in the absence of genetic modification for conversion of malonate semialdehyde to 3-HP; and

    ii) maintaining the combined hydrogen, carbon source, and microorganism cells for a suitable time and under conditions sufficient to produce malonate semialdehyde and convert the malonate semialdehyde to 3-HP.

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