INTRAVASCULAR DIAGNOSTIC AND THERAPEUTIC SAMPLING DEVICE

• US 20110125136A1
• Filed: 01/25/2011
• Published: 05/26/2011
• Est. Priority Date: 06/08/2005
• Status: Abandoned Application

• Current Assignee: Danny Petrasek, Derek Rinderknecht, Morteza Gharib
• Original Assignee: Danny Petrasek, Derek Rinderknecht, Morteza Gharib
• Inventors: Petrasek, Danny, Gharib, Morteza, Rinderknecht, Derek
• Application Number:
  US13/013,733
• Publication Number:
  US 20110125136A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: B01L 2200/10 Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
• CPC Class Codes: B01L 2300/0864 comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 2400/0439 ultrasonic vibrations, vibrating piezo elements
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/082 Active control of flow resistance, e.g. flow controllers
• CPC Class Codes: B01L 2400/084 Passive control of flow resistance
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: G01N 2035/00148 Test cards, e.g. Biomerieux or McDonnel multiwell test cards
• CPC Class Codes: G01N 2035/1034 Transferring microquantities of liquid

Abstract

A device and methods for continuous precision blood sampling from a patient with a micro impedance pump as the driver in a microfluidic system. Depending on the needs of medical technologies, the micro impedance pump in the intravascular diagnostic and therapeutic sampling system serves in a forward pumping function for blood sampling, in a backward infusing for therapeutic treatment, and in a valving function for controlling fluid flow.

Claims

1-13. -13. (canceled)

14. A method of continuously or intermittently monitoring a physiological index or marker of a patient, comprising:

(a) providing a microfluidic system having at least one microchannel, a fluid reservoir for flushing, a grid of sample wells, and a micro impedance pump in said at least one micro channel;

(b) initiating the micro impedance pump for a predetermined duration or by a flow control sensor in a manner to supply a precise amount of blood through the at least one microchannel to at least one sample well for sample analysis;

(c) flushing the at least one micro channel and the sample wells to rid of waste fluid;

(d) repeating steps b and c; and

(e) analyzing the blood in the at least one sample well for the physiological index or marker.

15. The method of claim 14, wherein the physiological index is a level of electrolytes selected from a group consisting of Na, K, Cl, HCO, Ca, Mg, and combinations thereof.

16. The method of claim 14, wherein the physiological marker is selected from the group consisting of glucose, cholesterol, and C-reactive protein.

17. The method of claim 14, wherein the micro impedance pump comprises an actuator to drive said pump.

18. The micro fluidic system of claim 17, wherein the actuator is selected from the group consisting of a piezoelectric actuator, an electromagnetic actuator, a pneumatic actuator, a polymeric actuator, and a hydraulic actuator.

19. The method of claim 14, wherein the micro impedance pump serves in a forward pumping function for blood sampling, in a backward infusing function for therapeutic treatment, and in a valving function for controlling fluid flow.