IMPLANTABLE TISSUE STRUCTURE MODIFIERS AND METHODS FOR USING THE SAME

• US 20110125169A1
• Filed: 11/19/2010
• Published: 05/26/2011
• Est. Priority Date: 11/20/2009
• Status: Active Grant

• Current Assignee: Peter Karl Johansson
• Original Assignee: Peter Karl Johansson
• Inventors: Johansson, Peter Karl
• Granted Patent: US 8,821,538 B2
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/0682 for applying U-shaped staples or clamps, e.g. without a forming anvil
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/083 Clips, e.g. resilient
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 17/1227 Spring clips
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/0645 being elastically deformed for insertion
• CPC Class Codes: A61F 2/2445 Annuloplasty rings in direct contact with the valve annulus
• CPC Class Codes: A61F 2/2466 Delivery devices therefor
• CPC Class Codes: A61L 2400/16 Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: C08L 2201/12 Shape memory

Abstract

Implantable tissue structure modification devices are provided. Aspects of the tissue structure modification devices include first and second tissue securers separated by a contraction region, wherein the device is configured to be implanted at a cardiac location and assume a first constrained length that is longer than a second relaxed length. Also provided are methods of using the devices for tissue structure modification, as well as delivery systems and kits that find use in the methods. The devices and methods of the invention find use in a variety of different applications, including valve (e.g., mitral valve) structure modification.

Claims

1. An implantable tissue structure modification device, the device comprising:

first and second tissue securers separated by a contraction region, wherein the device is configured to be implanted at a cardiac location and assume a first constrained length that is longer than a second relaxed length.

2. The device according to claim 1, wherein the device comprises a superelastic material.

3. The device according to claim 1, wherein the tissue securers are tines.

4. The device according to claim 1, wherein the tissue securers are hooks.

5. The device according to claim 4, wherein the hooks comprise barbs.

6. The device according to claim 1, wherein the contraction region is structured to assume a linear constrained configuration and a curvilinear relaxed configuration.

7. The device according to claim 1, wherein the device has an arced configuration when present in a relaxed state.

8. The device according to claim 1, wherein the device has a second moment of inertia to assume a desired orientation during delivery and implantation.

9. The device according to claim 1, wherein the device is configured to be associated in a constrained configuration with a minimally invasive deployment device.

10. The device according to claim 8, wherein the device comprises a passageway.

11. The device according to claim 9, wherein the passageway is associated with the tissue securer.

12. The device according to claim 1, wherein the device comprises third and fourth tissue securers separated by the contraction region.

13. The device according to claim 11, wherein the device comprises fifth and sixth tissue securers associated with the contraction region.

14. The device according to claim 1, wherein the cardiac location is a ventricle wall location.

15. The device according to claim 13, wherein the ventricle wall location is a mitral valve ventricle wall location.

16. The device according to claim 1, wherein the first constrained length is at least about 20% longer than the second relaxed length.

17. A method of modifying a tissue location in a subject, the method comprising:

positioning a device according to claim 1 in a first constrained configuration at the tissue location; and

reducing constraining force from the device in a manner sufficient for the device to assume a second relaxed configuration to engage tissue and modify the tissue location.

18. The method according to claim 16, wherein the device is positioned with a minimally invasive deployment device.

19. The method according to claim 17, wherein the minimally invasive deployment device comprises a catheter.

20. The method according to claim 18, wherein the catheter comprises a deployment wire that associates the implantable device to the deployment device in the first constrained configuration and the method comprises moving the deployment wire in a manner sufficient for the implantable device to dissociate from the deployment device and assume the second relaxed configuration.

22. The system according to claim 20, wherein the deployment device comprises a deployment wire that associates the implantable device to the deployment device in the first constrained configuration and wherein movement of the deployment wire dissociates the implantable device from the deployment device to assume a second relaxed configuration.

24. The kit according to claim 22, wherein the kit comprises a second implantable tissue structure modification device dimensioned differently from the first implantable tissue structure modification device.

25. The kit according to claim 22, wherein the kit comprises a guide.

26. The kit according to claim 22, wherein the kit comprises a guidewire.

21. A system comprising:

(a) a minimally invasive deployment device; and

(b) an implantable tissue structure modification device comprising first and second tissue securers separated by a contraction region;

wherein the implantable device is associated in a first constrained configuration with the minimally invasive deployment device.

23. A kit comprising:

(a) a minimally invasive deployment device; and

(b) a first implantable tissue structure modification device, the implantable device comprising first and second tissue securers separated by a contraction region.