METHOD FOR PRODUCING NANOSTRUCTURES ON A SURFACE OF A MEDICAL IMPLANT
First Claim
1. A method for producing a plurality of nanostructures on a surface of a medical implant, the method comprising:
- presoaking the implant in a solution;
providing an anodization electrolyte solution;
providing a cathode;
submerging the cathode and medical implant in the electrolyte solution;
applying a voltage for a set time period between the medical implant and the cathode to generate a plurality of nanostructures on the surface of the medical implant; and
removing the medical implant from the electrolyte solution and rinsing the surface of the medical implant.
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Accused Products
Abstract
A method for treating a surface of a medical implant to create nanostructures on the surface that results in increased in-vivo chondrocyte adhesion to the surface. Further, disclosed is a method to fabricate a drug delivery system. The drug delivery system includes a medical implant that has undergone a surface treatment process that results in the modification of the surface configuration and topography. The modified surface acts as a depot or reservoir for loaded biological material, biologic agents or pharmaceutical products. Additionally, a device for delivering pharmaceutical products or other biological materials is disclosed. The device includes integrally attached nanostructures that retain or adsorb the loaded pharmaceutical products and/or biological materials. Further disclosed is a medical implant that includes a surface configured to allow for and regulate protein adsorption. The surface of the medical implant has a layer of nanostructures rigidly attached with varying porosity and orientation that allow for surface protein adsorption to be controlled.
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Citations
37 Claims
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1. A method for producing a plurality of nanostructures on a surface of a medical implant, the method comprising:
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presoaking the implant in a solution; providing an anodization electrolyte solution; providing a cathode; submerging the cathode and medical implant in the electrolyte solution; applying a voltage for a set time period between the medical implant and the cathode to generate a plurality of nanostructures on the surface of the medical implant; and removing the medical implant from the electrolyte solution and rinsing the surface of the medical implant. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for fabricating a medical implant with increased chondrocyte functionality, the method comprising:
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obtaining a medical implant, the medical implant being fabricated from at least one of a metallic material, a polymer, a ceramic and a composite; and treating a surface of the medical implant to modify the surface topography resulting in increased chondrocyte functionality. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method for fabricating a drug delivery system for use in a living body, the method comprising:
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obtaining a medical implant, the medical implant being fabricated from at least one of a metallic material, a polymer, a ceramic and a composite; and treating a surface of the medical implant to modify the surface topography resulting in increased surface roughness, thereby fabricating a system by which a biological material or a pharmaceutical product can be retained and delivered to a part of a living body. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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- 23. A device for delivering a drug or biologic agent within a living being comprising, a medical implant with a surface, wherein integrally attached to the surface are a plurality of nanostructures, the nanostructures being configured to retain or adsorb the drug or biologic agent.
- 29. A medical implant having a surface configured for regulating protein adsorption, the surface comprising a plurality of nanostructures, the nanostructures being formed and integrally attached to the surface following the implant undergoing a surface treatment process before implantation into the body.
Specification