PRO-FLUORESCENT PROBES
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Abstract
The present invention provides a novel class of pro-fluorescent probes for reactive oxygen species (ROS). One exemplary probe is mitochondria peroxy yellow 1 (MitoPY1), a new type of flurophore for imaging mitochondrial H2O2 in living cells with ROS and spatial specificity. The invention also provides methods of using pro-fluorescent probes to detect analytes. One exemplary method comprises using a pro-fluorescent probe of the invention to detect an explosive.
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Citations
43 Claims
- 1. A pro-fluorescent compound having the formula:
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19. A compound having a structure selected from
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33. A method for assaying a sample for an explosive, said method comprising:
(a) contacting said sample with a pro-fluorescent compound of the following formula, - View Dependent Claims (34, 35, 36, 37, 38, 39)
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40. A method for assaying a sample for an explosive, said method comprising:
(a) contacting said sample with a pro-fluorescent compound of the following formula, - View Dependent Claims (41, 42, 43)
Specification