COMPOSITION COMPRISING ESTRONE AND HYDROCORTISONE FOR USE IN THE TOPICAL TREATMENT OF BALDNESS

• US 20110130372A1
• Filed: 07/24/2009
• Published: 06/02/2011
• Est. Priority Date: 07/29/2008
• Status: Abandoned Application

• Current Assignee: Andrea Marliani, Gaetano Agostinacchio, Marino Salin
• Original Assignee: Andrea Marliani, Gaetano Agostinacchio, Marino Salin
• Inventors: Salin, Marino, Marliani, Andrea, Agostinacchio, Gaetano
• Application Number:
  US13/003,897
• Publication Number:
  US 20110130372A1
• Time in Patent Office: Days
• US Class Current: 514/170
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/4045 Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/566 having an oxo group in position 17, e.g. estrone
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61P 17/14 for baldness or alopecia

Abstract

The present invention relates to a composition comprising an association of active substances for use in the topical treatment of baldness, particularly of male pattern and female pattern androgenetic alopecia.

Claims

1. A composition comprising:

(a) from 0.005 to 0.2% by weight of estrone;

(b) from 0.005 to 0.2% by weight of hydrocortisone or an ester thereof or a pharmaceutically acceptable salt thereof, for use in topical treatment of baldness, particularly of androgenetic alopecia.

2. Composition according to claim 1, comprising:

(a) from 0.01 to 0.1% by weight of estrone;

(b) from 0.01 to 0.1% by weight of hydrocortisone or an ester thereof or a pharmaceutically acceptable salt thereof.

3. Composition according to claim 1, further comprising:

(c) from 0.02 to 6% by weight, preferably from 0.5 to 4% by weight, of progesterone.

4. Composition according to claim 1, wherein hydrocortisone is esterified in position 17 or 21.

5. Composition according to claim 4, wherein hydrocortisone is hydrocortisone butyrate or hydrocortisone acetate.

6. Composition according to claim 1, further comprising minoxidil (3-hydroxy-2-imino-6-(1-piperidyl) pyrimidin-4-amine) or a pharmaceutically acceptable salt thereof, in an amount of from 1 to 10% by weight.

7. Composition according to claim 1, further comprising melatonin in an amount of from 0.01 to 0.1% by weight.

8. Composition according to claim 1, in the form of a hydroalcoholic solution.

9. Composition according to claim 1, in the form of a cream, an emulsion or a gel.

10. Method for topical treatment of baldness, particularly of androgenetic alopecia, which comprises topically administering a composition according to claim 1 to a patient in need thereof.