PYRROLINONE COMPOUNDS AS INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF
2 Assignments
0 Petitions
Accused Products
Abstract
Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for preventing or inhibiting bacterial proliferation as well as methods for preventing, treating, and/or managing a bacterial infection using such compounds and compositions.
8 Citations
13 Claims
- 1. A compound having the following formula I:
- 8. A pharmaceutical composition comprising a compound having the following formula I:
-
11. A method of preventing or inhibiting replication of a bacterial organism, comprising contacting the bacterial organism with an effective amount of a compound having the following formula I:
-
12. A method of preventing, treating or managing a bacterial infection in a subject, comprising administering to a subject in need thereof an effective amount of a compound having the following formula I:
-
13. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
Specification