MULTI-MODALITY NEUROMODULATION OF BRAIN TARGETS
First Claim
1. A method of modulating deep-brain targets using multiple therapeutic modalities, the method comprising:
- applying a plurality of therapeutic modalities to a deep-brain target,applying power to each of the on-line therapeutic modalities via a control circuit thereby neuromodulating the activity of the deep brain target regions, andworking in coordination with the off-line therapeutic modalities.
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Abstract
Disclosed are methods and systems and methods for deep or superficial deep-brain stimulation using multiple therapeutic modalities. These impact multiple points in a neural circuit or one or multiple points in multiple neural circuits to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Modality examples are implanted deep-brain stimulators (DBS), Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), implanted optical stimulation, focused ultrasound, RF stimulation, vagus nerve stimulation, other-implant stimulation, functional stimulation, and drugs. Some targets may be up-regulated and others down-regulated. Coordinated control is provided, as applicable, for control of the direction of the energy emission, intensity, session duration, frequency, pulse-train duration, phase, and numbers of sessions, if and as applicable, for neurormodulation of neural targets. Use of ancillary monitoring or imaging to provide feedback may be applied.
132 Citations
37 Claims
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1. A method of modulating deep-brain targets using multiple therapeutic modalities, the method comprising:
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applying a plurality of therapeutic modalities to a deep-brain target, applying power to each of the on-line therapeutic modalities via a control circuit thereby neuromodulating the activity of the deep brain target regions, and working in coordination with the off-line therapeutic modalities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of modulating deep-brain targets using multiple therapeutic modalities for the treatment of pain, the method comprising:
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applying down-regulation via ultrasound to the Dorsal Anterior Cingulate Gyrus, applying down-regulation via ultrasound to the Cingulate Genu, applying down-regulation via Transcranial Magnetic Stimulation to the Insula, applying down-regulation via ultrasound to the Caudate Nucleus, and applying down-regulation via Deep Brain Stimulation of the Thalamus. - View Dependent Claims (24, 25)
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26. A method of modulating deep-brain targets using multiple therapeutic modalities for the treatment of depression, the method comprising:
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applying down-regulation via ultrasound to the Orbito-Frontal Cortex, applying up-regulation via ultrasound to the Dorsal Anterior Cingulate Gyrus, applying down-regulation via ultrasound to the Subgenu Cingulate, applying down-regulation via ultrasound to the Cingulate Genu, applying up-regulation via Transcranial Magnetic Stimulation to the right Insula, applying down-regulation via Transcranial Magnetic Stimulation to the left Insula, applying up-regulation via Deep Brain Stimulation to the Nucleus Accumbens, applying up-regulation via ultrasound to the Caudate Nucleus, applying down-regulation via radiosurgery of the Amygdala, and applying down-regulation via Deep Brain Stimulation of the Thalamus. - View Dependent Claims (27, 28)
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29. A method of modulating deep-brain targets using multiple therapeutic modalities for the treatment of addiction, the method comprising:
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applying down-regulation via ultrasound to the Orbito-Frontal Cortex, applying up-regulation via ultrasound to the Dorsal Anterior Cingulate Gyrus, applying down-regulation via Transcranial Magnetic Stimulation to the Insula, applying down-regulation via radiosurgery of the Nucleus Accumbens, and applying down-regulation via Deep Brain Stimulation of the Globus Pallidus. - View Dependent Claims (30, 31)
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32. A method of modulating deep-brain targets using multiple therapeutic modalities for the treatment of obesity, the method comprising:
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applying down-regulation via Transcranial Magnetic Stimulation of the Orbito-Frontal Gyrus, applying down-regulation via ultrasound to the Hypothalamus, applying down-regulation via Transcranial Magnetic Stimulation to the Insula, and applying down-regulation via radiosurgery of the Lateral Hypothalamus. - View Dependent Claims (33, 34)
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35. A method of modulating deep-brain targets using multiple therapeutic modalities for the treatment of epilepsy, the method comprising:
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applying down-regulation via Transcranial Magnetic Stimulation of the Temporal Lobe, applying down-regulation via radiosurgery of the Amygdala, applying down-regulation via ultrasound to the Hippocampus, applying up-regulation via Vagus Nerve Stimulation of the Thalamus, and applying down-regulation via Deep Brain Stimulation of the Cerebellum. - View Dependent Claims (36, 37)
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Specification