Pacing and Stimulation Apparatus and Methods

• US 20110130809A1
• Filed: 11/13/2009
• Published: 06/02/2011
• Est. Priority Date: 11/13/2008
• Status: Abandoned Application

• Current Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark
• Application Number:
  US12/600,586
• Publication Number:
  US 20110130809A1
• Time in Patent Office: Days
• US Class Current: 607/62
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence

Abstract

System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

Claims

1. A device, comprising:

one or more lead integrated circuits to programmably control one or more variability parameters; and

one or more electrodes to provide electrical stimulation, each electrode individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter.

2. The device of claim 1, wherein the variability parameters is selected from a group consisting essentially of a voltage variability parameter;

a spread spectrum variability parameter;

a pacing variability parameter;

a delay variability parameter;

a frequency variability parameter;

an interval variability parameter;

an amplitude variability parameter;

a component variability parameter;

a state variability parameter;

a blocking variability parameter;

a potential variability parameter; and

a focus variability parameter.

3. The device of claim 2, wherein the voltage variability parameter comprises varying a voltage associated with one or more electrodes.

4. The device of claim 2, wherein the pacing variability parameter comprises pseudo-randomly varying a pace of electrical stimuli.

5. The device of claim 2, wherein the state variability parameter comprises selectively activating or deactivating one or more electrodes.

6. The device of claim 2, wherein the component variability parameter comprises individual addressability of the one or more electrodes by the lead integrated circuit.

7. The device of claim 6, wherein the electrodes are configured as segmented electrode satellites.

8. The device of claim 7, wherein the segmented electrode satellites comprise at least one of a four-segmented electrode and a six-segmented electrode.

9. The device of claim 6, wherein the electrodes are configured in an array of electrodes.

10. The device of claim 7, wherein the array of electrodes comprises an array of arrays.

11. The device of claim 2, wherein the focus variability parameter comprises alternating between voltages that are positive or negative associated with a first group of electrodes while maintaining a neutral voltage associated with a second group of electrodes.

12. The device of claim 1, wherein at least one of the one or more variability parameters is generated via a scheme selected from a group consisting of a random generation scheme and a pseudo-random generation scheme.

13. The device of claim 1, further comprising:

a bus coupled to the one or more lead integrated circuits; and

a power supply associated with the bus.

14. A method, comprising:

programmably controlling one or more variability parameters with one or more lead integrated circuits; and

generating electrical stimulation based on the one or more variability parameters via one or more electrodes, each electrode individually addressable by at least one of the lead integrated circuits.

15. The method of claim 14, wherein the variability parameters is selected from a group consisting essentially of a voltage variability parameter;

a spread spectrum variability parameter;

a pacing variability parameter;

a delay variability parameter;

a frequency variability parameter;

an interval variability parameter;

an amplitude variability parameter;

a component variability parameter;

a state variability parameter;

a blocking variability parameter;

a potential variability parameter; and

a focus variability parameter.

16. The method of claim 15, wherein the voltage variability parameter comprises varying a voltage associated with one more electrodes.

17. The method of claim 15, wherein the pacing variability parameter comprises pseudo-randomly varying a pace of electrical stimuli.

18. The method of claim 15, wherein the state variability parameter comprises selectively activating or deactivating one or more electrodes.

19. The method of claim 15, wherein the component variability parameter comprises individual addressability of the one or more electrodes by the lead integrated circuit.

20. The method of claim 19, wherein the electrodes are configured as segmented electrode satellites.

21. The method of claim 20, wherein the segmented electrode satellites comprise at least one of a four-segmented electrode and a six-segmented electrode.

22. The method of claim 19, wherein the electrodes are configured in an array of electrodes.

23. The method of claim 20, wherein the array of electrodes comprises an array of arrays.

24. The method of claim 15, wherein the focus variability parameter comprises alternating between voltages that are positive or negative associated with a first group of electrodes while maintaining a neutral voltage associated with a second group of electrodes.

25. The method of claim 14, wherein at least one of the one or more variability parameters is generated via a scheme selected from a group consisting of a random generation scheme and a pseudo-random generation scheme.

26. A system comprising:

one or more lead integrated circuits, each lead integrated circuit having;

a programming module to programmably control one or more variability parameters; and

one or more electrodes, each electrode individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter.

27. A method for use with a lead having at least first and second satellites along its length, each satellite having at least two electrodes communicatively coupled thereto, the lead having at least one conductor coupled to the satellites, the total number of electrodes coupled with the satellites along the lead exceeding the number of conductors in the lead, the method comprising the steps of:

by means of control signals transmitted along the lead to the satellites, closing solid-state switches in the satellites, causing at least one electrode at the at least first satellite to be shorted to the at least one conductor, and at the same time, causing at least one electrode at the at least second satellite to be shorted to the at least one conductor, whereby the at least one electrode at the at least first satellite is shorted to the at least one electrode at the at least second satellite;

ceasing the shorting of the at least one electrode at the at least first satellite to the at least one electrode at the at least second satellite;

passing a stimulus signal along the lead to a selected electrode;

ceasing the passing of a stimulus signal along the lead to the selected electrode;

by means of control signals transmitted along the lead to the satellites, closing solid-state switches in the satellites, causing at least one electrode at the at least first satellite to be shorted to the at least one conductor, and at the same time, causing at least one electrode at the at least second satellite to be shorted to the at least one conductor, whereby the at least one electrode at the at least first satellite is shorted to the at least one electrode at the at least second satellite; and

ceasing the shorting of the at least one electrode at the at least first satellite to the at least one electrode at the at least second satellite.

28. The method of claim 27 wherein the selected electrode is the same as the at least one electrode of the at least first satellite.

31. The method of claim 27 or claim 29 wherein the lead has two conductors along its length.

29. A method for use with a lead having at least first and second satellites along its length, each satellite having at least two electrodes communicatively coupled thereto, the lead having at least one conductor coupled to the satellites, the total number of electrodes coupled with the satellites along the lead exceeding the number of conductors in the lead, the method comprising the steps of:

by means of control signals transmitted along the lead to the satellites, closing solid-state switches in the satellites, causing a first at least one electrode at the at least first satellite to be shorted to a second at least one electrode at the at least first satellite;

ceasing the shorting of the first at least one electrode at the at least first satellite to be shorted to the second at least one electrode at the at least first satellite;

passing a stimulus signal along the lead to a selected electrode;

ceasing the passing of a stimulus signal along the lead to the selected electrode;

by means of control signals transmitted along the lead to the satellites, closing solid-state switches in the satellites, causing a first at least one electrode at the at least first satellite to be shorted to a second at least one electrode at the at least first satellite; and

ceasing the shorting of the first at least one electrode at the at least first satellite to be shorted to the second at least one electrode at the at least first satellite.

30. The method of claim 29 wherein the selected electrode is the same as the first at least one electrode of the at least first satellite.

32. A method for use with a driver,

the driver connected with a wire and a lead;

the lead having at least first and second satellites along its length, each satellite having at least two electrodes communicatively coupled thereto, the lead having at least one conductor coupled to the satellites, the total number of electrodes coupled with the satellites along the lead exceeding the number of conductors in the lead, the method comprising the steps of;

by means of control signals transmitted along the lead to the satellites, closing a solid-state switch in a first satellite, causing at least one electrode at the first satellite to be shorted to the at least one conductor, and at the same time, by means of a switch within the driver, the wire to be shorted to the at least one conductor, whereby the at least one electrode at the first satellite is shorted to the wire;

ceasing the shorting of the at least one electrode at the first satellite to the wire;

passing a stimulus signal along the lead to a selected electrode;

ceasing the passing of a stimulus signal along the lead to the selected electrode;

by means of control signals transmitted along the lead to the satellites, closing a solid-state switch in the first satellite, causing at least one electrode at the first satellite to be shorted to the at least one conductor, and at the same time, by means of a switch within the driver, causing the wire to be shorted to the at least one conductor, whereby the at least one electrode at the first satellite is shorted to the wire; and

ceasing the shorting of the at least one electrode at the first satellite to the wire.

33. The method of claim 32 wherein the lead has two conductors along its length.

34. The method of claim 32 wherein the wire and at least one electrode are in contact with tissue.

35. A method for use with a driver,

the driver having a conductive housing and connected to a lead;

the lead having at least first and second satellites along its length, each satellite having at least two electrodes communicatively coupled thereto, the lead having at least one conductor coupled to the satellites, the total number of electrodes coupled with the satellites along the lead exceeding the number of conductors in the lead, the method comprising the steps of;

by means of control signals transmitted along the lead to the satellites, closing a solid-state switch in a first satellite, causing at least one electrode at the first satellite to be shorted to the at least one conductor, and at the same time, by means of a switch within the driver, causing the housing to be shorted to the at least one conductor, whereby the at least one electrode at the first satellite is shorted to the housing;

ceasing the shorting of the at least one electrode at the first satellite to the housing;

passing a stimulus signal along the lead to a selected electrode;

ceasing the passing of a stimulus signal along the lead to the selected electrode;

by means of control signals transmitted along the lead to the satellites, closing a solid-state switch in the first satellite, causing at least one electrode at the first satellite to be shorted to the at least one conductor, and at the same time, by means of a switch within the driver, causing the housing to be shorted to the at least one conductor, whereby the at least one electrode at the first satellite is shorted to the housing; and

ceasing the shorting of the at least one electrode at the first satellite to the housing.

36. The method of claim 35 wherein the lead has two conductors along its length.

37. The method of claim 35 wherein the housing and at least one electrode are in contact with tissue.

38. A system comprising a driver,

the driver connectable with a lead and with a wire at respective connection points;

the lead having at least one conductor along its length, and having at least one chip along its length connected to the conductor, the chip connected to at least two electrodes, the number of electrodes exceeding the number of conductors along the length of the lead;

the chip comprising switches controllably and selectively connecting respective electrodes to the at least one conductor of the lead;

the driver comprising a switch controllably and selectively connecting the connection point of the wire to the connection point of the at least one conductor of the lead;

the driver comprising means for controlling the switches of the chip so as to connect at least one of the electrodes to the at least one conductor of the lead, while simultaneously controlling the switch of the driver so as to connect the connection point of the wire to the connection point of the at least one conductor of the lead.

39. The system of claim 38 wherein the lead is in sterile packaging.

40. The system of claim 39 wherein the driver is in sterile packaging.

41. A system comprising a driver,

the driver connectable with a lead at a connection point and having a conductive housing;

the lead having at least one conductor along its length, and having at least one chip along its length connected to the conductor, the chip connected to at least two electrodes, the number of electrodes exceeding the number of conductors along the length of the lead;

the chip comprising switches controllably and selectively connecting respective electrodes to the at least one conductor of the lead;

the driver comprising a switch controllably and selectively connecting the conductive housing to the connection point of the at least one conductor of the lead;

the driver comprising means for controlling the switches of the chip so as to connect at least one of the electrodes to the at least one conductor of the lead, while simultaneously controlling the switch of the driver so as to connect the conductive housing to the connection point of the at least one conductor of the lead.

42. The system of claim 41 wherein the lead is in sterile packaging.

43. The system of claim 42 wherein the driver is in sterile packaging.

44. A driver for use with a lead and with a wire, the lead of a type having at least one conductor and the lead receiving control signals by which the lead selectively connects the at least one conductor with an electrode in response to control signals;

the driver connectable with the lead and with the wire at respective connection points;

the driver comprising a switch controllably and selectively connecting the connection point of the wire to the connection point of the at least one conductor of the lead;

the driver comprising means for sending control signals disposed to control the lead so as to connect the electrode to the at least one conductor of the lead, while simultaneously controlling the switch of the driver so as to connect the connection point of the wire to the connection point of the at least one conductor of the lead.

45. The system of claim 44 wherein the driver is in sterile packaging.

46. A driver for use with a lead, the driver having a conductive housing, the lead of a type having at least one conductor and the lead receiving control signals by which the lead selectively connects the at least one conductor with an electrode in response to control signals;

the driver connectable with the lead at respective connection points;

the driver comprising a switch controllably and selectively connecting the conductive housing to the connection point of the at least one conductor of the lead;

the driver comprising means for sending control signals disposed to control the lead so as to connect the electrode to the at least one conductor of the lead, while simultaneously controlling the switch of the driver so as to connect the conductive housing to the connection point of the at least one conductor of the lead.

47. The system of claim 46 wherein the driver is in sterile packaging.