Bioabsorbable Polymeric Compositions and Medical Devices
First Claim
1. A stent comprising a blend formed from poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-caprolactone or trimethylcarbonate and where the wide-angle X-ray scattering (WAXS) exhibits 2θ
values of about 16.48 and about 18.76.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention comprises a stent forming a plurality of meandering elements comprising a blend formed from a polymer. The polymer comprises poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε-caprolactone or trimethylcarbonate. The poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε-caprolactone or trimethylcarbonate and the copolymer moiety molecular weight ranges from about 1.2 IV to about 4.8 IV. The meandering elements may be stretched to a modulus ranging from about 250000 PSI to about 550,000 PSI, one segment of the meandering element has a decreased cross-sectional area and may have a wide-angle X-ray scattering (WAXS) 2θ values of ranging from about 1 to about 35. In various embodiment, two, three or n segments of the meandering element have a decreased cross-sectional area and may also have a wide-angle X-ray scattering (WAXS) 2θ values of ranging from about 1 to about 35 after stretching. In another embodiment, all segments of the meandering element have a decreased cross-sectional area and may also have a wide-angle X-ray scattering (WAXS) 2θ values of ranging from about 1 to about 35 after stretching. The meandering element may comprise a helical winding, a circumferential winding or stent ringlet. The properties of the bioabsorbable polymers allow for both crimping and expansion of the stent. The crystal properties of the bioabsorbable polymers may change during crimping and/or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics.
136 Citations
25 Claims
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1. A stent comprising a blend formed from poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-caprolactone or trimethylcarbonate and where the wide-angle X-ray scattering (WAXS) exhibits 2θ
values of about 16.48 and about 18.76. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 19, 20, 23)
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-
14. A stent comprising a blend formed from poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-caprolactone or trimethylcarbonate, wherein there is at least about 95% (w/w) amorphous material in the stent. - View Dependent Claims (15, 16)
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-
21. A stent comprising a blend formed from poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
-caprolactone or trimethylcarbonate and where the wide-angle X-ray scattering (WAXS) exhibits 2θ
values of about 16.65 and about 18.96. - View Dependent Claims (22, 24, 25)
- -caprolactone or trimethylcarbonate wherein, the poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε
Specification