MULTIPLE PHASE CROSS-LINKED COMPOSITIONS AND USES THEREOF
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Accused Products
Abstract
The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.
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Citations
55 Claims
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1-37. -37. (canceled)
- 38. A controlled release hydrogel pharmaceutical composition comprising a homogenous matrix of a cross-linked hydrophilic polymer in an aqueous phase, and an oil phase or solid phase suspended therein, said hydrogel comprising at least one therapeutic agent, wherein at least one of said aqueous phase and said oil phase or said solid phase comprises a therapeutic agent.
Specification