IMMUNODETECTION PROBE AND METHOD OF IMMUNODETECTION USING THE SAME
First Claim
1. An immunodetection probe, comprising:
- a needle structure configured to be inserted into an organic tissue, wherein the needle structure comprises a compartment;
a dialysis membrane configured to isolate the compartment from the organic tissue;
a detection device comprising a detection portion and a plurality of receptors, wherein the plurality of receptors are disposed on an end surface of the detection portion for conjugating a target antibody, and the detection portion is disposed in the compartment;
a first optical fiber coupled to the needle structure and configured to introduce light incident on photo-induced molecules adjacent to the end surface of the detection portion so as to cause a change in the pH level of the solution adjacent to the end surface of the detection portion; and
a pair of tubes connected to the compartment and configured to transport the solution containing the photo-induced molecules into the compartment.
1 Assignment
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Accused Products
Abstract
An immunodetection probe comprises a needle structure having a compartment and configured to be inserted into an organic tissue, a dialysis membrane configured to isolate the compartment from the organic tissue, a detection device having a detection portion and a plurality of receptors, a first optical fiber coupled to the needle structure, and a pair of tubes connected to the compartment. The plurality of receptors are disposed on an end surface of the detection portion for conjugating a target antibody, wherein the detection portion is disposed in the compartment. The first optical fiber is configured to introduce light incident on photo-induced molecules adjacent to the end surface of the detection portion so as to cause a change in the pH level of the solution adjacent to the end surface of the detection portion. The pair of tubes is configured to transport the solution containing the photo-induced molecules into the compartment.
18 Citations
26 Claims
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1. An immunodetection probe, comprising:
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a needle structure configured to be inserted into an organic tissue, wherein the needle structure comprises a compartment; a dialysis membrane configured to isolate the compartment from the organic tissue; a detection device comprising a detection portion and a plurality of receptors, wherein the plurality of receptors are disposed on an end surface of the detection portion for conjugating a target antibody, and the detection portion is disposed in the compartment; a first optical fiber coupled to the needle structure and configured to introduce light incident on photo-induced molecules adjacent to the end surface of the detection portion so as to cause a change in the pH level of the solution adjacent to the end surface of the detection portion; and a pair of tubes connected to the compartment and configured to transport the solution containing the photo-induced molecules into the compartment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of immunodetection, comprising the steps of:
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inserting a needle structure of an immunodetection probe into an organic tissue, wherein the needle structure comprises a compartment and a detection device, and the detection device comprises a detection portion and a plurality of receptors, wherein the plurality of receptors are disposed on an end surface of the detection portion for conjugating a target antibody, and the detection portion is disposed in the compartment; detecting the existence of the target antibody conjugated with the receptors; transporting the solution containing the photo-induced molecules into the compartment; and introducing the light incident on the photo-induced molecules adjacent to the end surface of the detection portion so as to cause a change in the pH level of the solution adjacent to the end surface of the detection portion for dissociating the target molecule conjugated with the receptors. - View Dependent Claims (26)
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Specification