PROCESSES FOR PREPARING PIPERAZINIUM SALTS OF KMUP AND USE THEREOF
First Claim
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1. A complex compound, comprising a structure being one of
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Abstract
A series of monoquarternary piperazium salts including a structure of a formula I or II are provided. In formula I or II, R1, Ra, and RX are as defined in the specification. The monoquarternary piperazium salt of KMUP or piperazine disclosed in the present invention is characterized by being presented in a pro-drug form and having various pharmaceutical functions.
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Citations
16 Claims
- 1. A complex compound, comprising a structure being one of
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10. A method for preparing a complex compound, comprising :
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providing one of a KMUP salt and a piperazinium salt; reacting one of the KMUP salt and the piperazinium salt with a reacting compound containing a carboxylic group donated from one selected from a group consisting of a statin, a fibric acid, a fibric acid derivative, a non-steroid anti-inflammatory (NSAIDs), an anti-allergy drug, an anti-diabetic drug and an anti-asthmatic drug; and forming the complex compound being a quaternary ammonium salt. - View Dependent Claims (11, 12)
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13. A pharmaceutical composition, comprising :
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an effective amount of one of a KMUP salt and a piperazinium salt; and an effective amount of a compound containing a carboxylic group donated from one selected from a group consisting of a statin, a non-steroid anti-inflammatory (NSAIDs), an anti-allergy drug, an anti-diabetic drug and an anti-asthmatic drug. - View Dependent Claims (14, 15, 16)
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Specification