SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
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Abstract
This invention comprises the novel compounds of formula (I)
wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
64 Citations
18 Claims
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1-12. -12. (canceled)
- 13. A method of treating a disorder related to the abnormal growth of cells or the abnormal growth of transformed cells, in a mammalian subject in need of inhibition of such abnormal cell growth, comprising administering to the subject a therapeutically effective amount of the compound of formula (I),
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16. A method of inhibiting abnormal cellular proliferative conditions caused by histone deacetylase (HDAC) activity, in a human subject in need of inhibition of histone deacetylase (HDAC) activity, comprising administering to the subject a therapeutically effective amount of the compound of formula (I),
- 17. A method of inhibiting tumor growth in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound of formula (I),
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