HIGH THROUGHPUT FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY
First Claim
1. A system for high-throughput detection of the presence of an analyte of interest in a sample, said system comprising:
- a) a multi-well plate sample container;
b) an automated means for successively transporting samples from the multi-well plate sample container to a transparent capillary contained within a sample holder;
c) an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the capillary, and wherein the radiation induces a signal which is emitted from the sample; and
,d) at least one linear array comprising;
i. a proximal end disposed in proximity to the sample holder and an end port distal from the proximal end;
ii. a plurality of optical fibers extending from the proximal end to a single end port and having a first end and a second end, wherein the first ends of the individual optical fibers are arranged substantially parallel and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and
iii. an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal.e) an end port assembly optically coupled to the single end port and to a detector.
2 Assignments
0 Petitions
Accused Products
Abstract
System for high-throughput detection of the presence of an analyte of interest in a sample, said system comprising a multi-well plate sample container; an automated means for successively transporting samples from the multi-well plate sample container to a transparent capillary contained within a sample holder; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the capillary, and wherein the radiation induces a signal which is emitted from the sample; and, at least one linear array comprising: a proximal end disposed in proximity to the sample holder and a single end port distal from the proximal end; a plurality of optical fibers extending from the proximal end to the end port and having a first end and a second end, wherein the first ends of the individual optical fibers are arranged substantially parallel and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal.
12 Citations
10 Claims
-
1. A system for high-throughput detection of the presence of an analyte of interest in a sample, said system comprising:
-
a) a multi-well plate sample container; b) an automated means for successively transporting samples from the multi-well plate sample container to a transparent capillary contained within a sample holder; c) an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the capillary, and wherein the radiation induces a signal which is emitted from the sample; and
,d) at least one linear array comprising; i. a proximal end disposed in proximity to the sample holder and an end port distal from the proximal end; ii. a plurality of optical fibers extending from the proximal end to a single end port and having a first end and a second end, wherein the first ends of the individual optical fibers are arranged substantially parallel and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and iii. an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal. e) an end port assembly optically coupled to the single end port and to a detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
Specification