Megalin-Based Delivery of Therapeutic Compounds to the Brain and Other Tissues
10 Assignments
0 Petitions
Accused Products
Abstract
The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
42 Citations
74 Claims
-
1-57. -57. (canceled)
-
58. A conjugate comprising a receptor associated protein (RAP) polypeptide and a therapeutic or diagnostic/investigational agent which is an antibody, wherein the RAP polypeptide consists of an amino acid sequence at least 80% identical to amino acids 221-323 of RAP (SEQ ID NO:
- 1) that retains megalin-binding activity.
- View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74)
Specification