Humanized antibodies that recognize beta amyloid peptide
First Claim
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1. A method for reducing neuritic burden in a subject in need thereof comprising administering to the subject an effective dose of a humanized immunoglobulin which binds to an epitope within amino acids 3-7 of beta amyloid peptide (Aβ
- ), wherein the immunoglobulin is of the IgG1 isotype, such that neuritic burden is reduced.
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Abstract
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.
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Citations
24 Claims
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1. A method for reducing neuritic burden in a subject in need thereof comprising administering to the subject an effective dose of a humanized immunoglobulin which binds to an epitope within amino acids 3-7 of beta amyloid peptide (Aβ
- ), wherein the immunoglobulin is of the IgG1 isotype, such that neuritic burden is reduced.
- View Dependent Claims (2, 3, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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4. A method for treating an amyloidogenic disease in a patient comprising administering to the patient an effective dose of a humanized immunoglobulin capable of reducing beta amyloid peptide (Aβ
- ) burden and neuritic dystrophy in the patient, wherein the immunoglobulin binds to an epitope within amino acids 3-7 of Aβ and
is of the IgG1 isotype, such that a beneficial therapeutic response in said patient is generated. - View Dependent Claims (5)
- ) burden and neuritic dystrophy in the patient, wherein the immunoglobulin binds to an epitope within amino acids 3-7 of Aβ and
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6. A method for reducing beta amyloid peptide (Aβ
- ) burden and neuritic dystrophy in a mammal comprising administering to the mammal an effective dose of a humanized immunoglobulin capable of reducing beta amyloid peptide (Aβ
) burden and neuritic dystrophy, wherein the immunoglobulin binds to an epitope within amino acids 3-7 of Aβ and
is of the IgG1 isotype, such that Aβ
burden and neuritic dystrophy are reduced. - View Dependent Claims (7, 8, 9)
- ) burden and neuritic dystrophy in a mammal comprising administering to the mammal an effective dose of a humanized immunoglobulin capable of reducing beta amyloid peptide (Aβ
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10. A method for treating an amyloidogenic disease in a patient comprising administering to the patient an effective dose of a humanized immunoglobulin which binds to soluble beta amyloid peptide (Aβ
- ) and reduces neuritic dystrophy in the patient, wherein the immunoglobulin binds to an epitope within amino acids 3-7 of Aβ and
is of the IgG1 isotype, such that a beneficial therapeutic response in said patient is generated. - View Dependent Claims (11)
- ) and reduces neuritic dystrophy in the patient, wherein the immunoglobulin binds to an epitope within amino acids 3-7 of Aβ and
Specification