COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON
First Claim
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1. A method of coating a medical device having an outer surface, the method comprising:
- selecting a cytostatic therapeutic agent;
selecting at least one excipient;
blending the cytostatic agent and excipient to define a coating; and
applying the coating to the outer surface of the medical device, wherein the cytostatic therapeutic agent and the at least one excipient have a weight ratio of about 20;
1 to about 1;
20, and further wherein the coating provides increased efficiency of therapeutic transfer to a body lumen.
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Abstract
A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
199 Citations
42 Claims
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1. A method of coating a medical device having an outer surface, the method comprising:
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selecting a cytostatic therapeutic agent; selecting at least one excipient; blending the cytostatic agent and excipient to define a coating; and applying the coating to the outer surface of the medical device, wherein the cytostatic therapeutic agent and the at least one excipient have a weight ratio of about 20;
1 to about 1;
20, and further wherein the coating provides increased efficiency of therapeutic transfer to a body lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of coating a medical device having an outer surface, the method comprising:
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selecting a cytostatic therapeutic agent; selecting at least one polymeric excipient; blending the cytostatic therapeutic agent and at least one polymeric excipient to define a coating; and applying the coating to at least one length of the outer surface of the medical device, wherein the at least one polymeric excipient has a polydispersity index from about 1.05 to about 10 and provides increased efficiency of therapeutic transfer to a body lumen. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A method of coating a medical device having an outer surface, the method comprising:
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selecting a cytostatic therapeutic agent; selecting at least one excipient; blending the cytostatic therapeutic agent and at least one excipient to define a coating; applying the coating to at least one length of the outer surface of the medical device; and inserting or implanting the coated medical device in a body lumen, wherein the coating has a dissolution rate of about 10 seconds to about 1 hour and provides an increased efficiency of therapeutic transfer to a body lumen. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A method of tuning the solubility of a coating for a medical device, the method comprising:
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selecting a first cytostatic therapeutic agent; selecting a first excipient; blending the first cytostatic agent and the first excipient to define a first coating, the first coating having a first dissolution rate; selecting a second cytostatic therapeutic agent; selecting a second excipient; blending the second cytostatic agent and second excipient to define a second coating, the second coating having a second dissolution rate;
wherein the first and second dissolution rates are different; andapplying the first and second coatings to at least one length of the outer surface of the medical device, the different dissolution rates defining a tunable solubility. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A method of coating a medical device, the method comprising:
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selecting a therapeutic agent; selecting at least one excipient; modifying the excipient; blending the therapeutic agent and the charged excipient to define a coating; and applying the modified excipient to an expandable member, wherein the coating provides desired delivery kinetics. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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Specification