Assay Apparatuses, Consumables and Methods
First Claim
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1. A kit for conducting luminescence assays in multi-well plates, the kit comprising:
- (a) a multi-well assay test plate comprising a plurality of assay wells for said assay;
(b) an auxiliary plate comprising a plurality of auxiliary wells, said auxiliary well comprising dry assay reagents for use in said assay with said assay test plate.
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Abstract
We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.
130 Citations
111 Claims
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1. A kit for conducting luminescence assays in multi-well plates, the kit comprising:
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(a) a multi-well assay test plate comprising a plurality of assay wells for said assay; (b) an auxiliary plate comprising a plurality of auxiliary wells, said auxiliary well comprising dry assay reagents for use in said assay with said assay test plate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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- 43. An auxiliary plate comprising a plurality of assay auxiliary well, said auxiliary well comprising dry assay reagents for use in an assay with a corresponding assay test plate.
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78. An apparatus for conducting a measurement in a multi-well assay test plate, said apparatus comprising
(a) a subassembly capable of supporting and translating said test plate to one or more components of said apparatus; - and
(b) an auxiliary plate subassembly, wherein said auxiliary plate comprises a plurality of auxiliary wells comprising dry assay reagents for use in an assay with said test plate. - View Dependent Claims (79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 111)
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96. A method for conducting a measurement in a multi-well assay test plate, said method comprising the steps of:
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(a) dispensing sample and/or reagent into an auxiliary well of an auxiliary plate, said auxiliary plate comprising a plurality of auxiliary wells, said plurality of auxiliary wells comprising dry assay reagents for use in an assay with said test plate; and (b) transferring sample and/or reagent from said auxiliary well to a well of a said assay test plate. - View Dependent Claims (97, 98, 99, 100, 101, 102, 103)
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104. A method for conducting a measurement in a multi-well assay test plate, said method comprising the steps of:
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(a) dispensing sample and/or reagent into an auxiliary well of a set of auxiliary wells in an auxiliary plate, said auxiliary plate comprising a plurality of auxiliary wells, said plurality of auxiliary wells comprising dry assay reagents for use in an assay with said test plate; (b) pre-treating said sample and/or reagent in one or more auxiliary wells of said set; (c) dispensing pre-treated sample and/or reagent from said one or more auxiliary wells of said set to a well of a said assay test plate; (d) repeating steps (a)-(c) with an additional sample and reagents in an additional set of auxiliary wells in said auxiliary plate, and an additional well of said test plate; (e) ejecting a used auxiliary plate; (f) repeating steps (a)-(c) with an additional auxiliary plate; and (g) ejecting a used assay test plate.
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- 105. A well-wash subassembly comprising a multi-tube array comprising a central dispensing tube element surrounded by a plurality of aspiration tube elements.
Specification