SYSTEMS AND METHODS FOR MAGNETIC-ASSISTED THERAPEUTIC AGENT DELIVERY
First Claim
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1. A system for magnetically-assisted delivery of a therapeutic agent, the system comprising:
- a carrier device comprising a carrier surface and first magnetic field generator generating a first magnetic field comprising magnetic flux lines extending through the carrier surface, wherein the first magnetic field comprises a first magnetic field strength at the carrier surface;
a plurality of discrete magnetic particles attracted to the carrier surface by the first magnetic field, wherein the discrete magnetic particles are associated with a therapeutic agent;
a release device comprising a second magnetic field generator generating a second magnetic field comprising magnetic flux lines extending through a release surface of the release device, wherein the second magnetic field generator is capable of generating the second magnetic field with a second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 2 centimeters or less from the carrier surface.
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Abstract
Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.
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Citations
20 Claims
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1. A system for magnetically-assisted delivery of a therapeutic agent, the system comprising:
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a carrier device comprising a carrier surface and first magnetic field generator generating a first magnetic field comprising magnetic flux lines extending through the carrier surface, wherein the first magnetic field comprises a first magnetic field strength at the carrier surface; a plurality of discrete magnetic particles attracted to the carrier surface by the first magnetic field, wherein the discrete magnetic particles are associated with a therapeutic agent; a release device comprising a second magnetic field generator generating a second magnetic field comprising magnetic flux lines extending through a release surface of the release device, wherein the second magnetic field generator is capable of generating the second magnetic field with a second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 2 centimeters or less from the carrier surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of delivering a therapeutic agent, the method comprising:
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positioning a carrier surface of a carrier device proximate selected internal tissue, wherein magnetic flux lines of a selected magnetic pole of a first magnetic field extend through the carrier surface; magnetically retaining a therapeutic agent to the carrier surface, wherein the therapeutic agent is associated with a plurality of magnetic particles; positioning a release device that comprises a release surface proximate the selected internal tissue, wherein the selected internal tissue is located between the release surface and the carrier surface, and wherein the release device comprises a second magnetic field generator generating a second magnetic field that extends through the release surface and towards the carrier surface; and delivering at least a portion of the therapeutic substance to the selected internal tissue by magnetically attracting at least a portion of the plurality of magnetic particles towards the release surface; wherein, proximate the carrier surface, the second magnetic field has a magnetic field strength greater than a magnetic field strength of the first magnetic field; and wherein the second magnetic field extending through the release surface comprises a magnetic pole facing the carrier device that is the same as the selected magnetic pole of the carrier device. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification