ENHANCEMENTS TO THE DETECTION OF PULMONARY EDEMA WHEN USING TRANSTHORACIC IMPEDANCE

• US 20110144526A1
• Filed: 02/23/2011
• Published: 06/16/2011
• Est. Priority Date: 05/11/2005
• Status: Active Grant

• Current Assignee: Jeffrey E. Stahmann, Jesse W. Hartley, John Hatlestad
• Original Assignee: Jeffrey E. Stahmann, Jesse W. Hartley, John Hatlestad
• Inventors: Stahmann, Jeffrey E., Hartley, Jesse W., Hatlestad, John
• Granted Patent: US 8,483,818 B2
• Time in Patent Office: Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/4878 Evaluating oedema

Abstract

This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.

Claims

1. A system comprising:

an implantable thoracic impedance measurement circuit configured to sense a thoracic impedance signal from a subject;

a parameter collection device configured to sense or receive physiologic information about the subject, the physiologic information including heart wall motion;

a pulmonary edema indicator coupled with the thoracic impedance measurement circuit to accept the thoracic impedance signal and coupled with the parameter collection device to accept the physiologic information, wherein the pulmonary edema indicator is configured to provide a pulmonary edema indication using the thoracic impedance signal and the physiologic information.

2. The system of claim 1, comprising a posture sensor adapted to sense a posture signal, the posture sensor being coupled with the pulmonary edema indicator, wherein the pulmonary edema indicator is configured to provide a pulmonary edema indication using the posture signal.

3. The system of claim 2, comprising a posture compensation module configured to compute a posture-compensated thoracic impedance signal from the thoracic impedance signal using the posture signal, wherein the pulmonary edema indicator is configured to determine the pulmonary edema indication using, at least in part, the posture-compensated thoracic impedance signal.

4. The system of claim 1, wherein:

the pulmonary edema indicator determines the pulmonary edema indication when the thoracic impedance signal is less than a thoracic impedance threshold; and

the pulmonary edema indicator includes a threshold adjustment module adapted to adjust the thoracic impedance threshold using, at least in part, physiologic information driven by the presence or absence of pulmonary edema.

5. The system of claim 1, comprising a frequency selective filter circuit configured to extract from the thoracic impedance signal a near-DC thoracic impedance signal by attenuating frequency components having a value greater than about 0.05 Hz, and wherein the pulmonary edema indicator is configured to determine the pulmonary edema indication using, at least in part, the near-DC thoracic impedance signal.

6. The system of claim 1, comprising:

a blood impedance measurement circuit configured to sense a blood impedance signal from the subject; and

a blood impedance correction module coupled with the blood impedance measurement circuit, wherein the blood impedance correction module is configured to extract from the thoracic impedance signal a blood resistivity-influenced component using the blood impedance signal, and wherein the pulmonary edema indicator is adapted to determine the pulmonary edema indication using, at least in part, a blood resistivity-compensated thoracic impedance signal.

7. The system of claim 1, comprising a therapy control module coupled to the pulmonary edema indicator, wherein the therapy control module is configured to adjust or initiate a therapy based, at least in part, on the pulmonary edema indication, and wherein the therapy includes at least one of:

cardiac rhythm management therapy, dietary therapy, and breathing assistance therapy.

8. The system of claim 1, wherein the physiologic information includes at least one heart sound.

9. The system of claim 1, wherein the physiologic information includes a creatinine level.

10. A method comprising:

implantably sensing a thoracic impedance signal from the thorax of a subject;

sensing or receiving physiologic information about the subject, the physiologic information including heart wall motion;

determining, using a processor circuit, a pulmonary edema indication using the thoracic impedance signal and the physiologic information, wherein determining the pulmonary edema indication includes comparing the thoracic impedance signal to a thoracic impedance threshold.

11. The method of claim 10, comprising sensing a posture signal corresponding to the posture of the subject, wherein determining, using the processor circuit, the pulmonary edema indication includes using the sensed posture signal.

12. The method as recited in claim 11, comprising one or more of:

filtering the thoracic impedance signal to obtain a near-DC thoracic impedance signal, compensating the thoracic impedance signal to attenuate or remove a posture-influenced component of the thoracic impedance signal, and compensating the thoracic impedance signal to attenuate or remove a blood resistivity-influenced component of the thoracic impedance signal,

wherein determining the pulmonary edema indication includes comparing one or a combination of;

the near-DC thoracic impedance signal, a posture-compensated thoracic impedance signal, and a blood resistivity-compensated thoracic impedance signal, to the thoracic impedance threshold.

13. The method as recited in claim 10, comprising:

increasing the sensitivity of the pulmonary edema indication, including computing a change in the thoracic impedance threshold using the physiologic information;

adjusting the thoracic impedance threshold using the computed change; and

determining the pulmonary edema indication with increased sensitivity using an adjusted thoracic impedance threshold.

14. The method as recited in claim 10, comprising alerting a user in response to the pulmonary edema indication.

15. The method as recited in claim 10, comprising providing a therapy to the subject in response to the pulmonary edema indication, wherein the therapy includes one or a combination of:

cardiac rhythm management therapy, dietary therapy, and sleep disordered breathing therapy.

16. The method of claim 10, wherein sensing or receiving the physiologic information includes sensing or receiving the physiologic information including at least one heart sound.

17. The method of claim 10, wherein sensing or receiving the physiologic information includes sensing or receiving the physiologic information including a creatinine level.

18. A system comprising:

means for implantably sensing a thoracic impedance signal from the thorax of a subject;

means for sensing or receiving physiologic information about the subject, the physiologic information including heart wall motion;

means for determining a pulmonary edema indication using the thoracic impedance signal and the physiologic information, wherein determining the pulmonary edema indication includes comparing the thoracic impedance signal to a thoracic impedance threshold.

19. The system of claim 18, wherein the physiologic information includes sensing or receiving the physiologic information including at least one heart sound.

20. The system of claim 18, wherein the physiologic information including a creatinine level.