Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields
First Claim
1. A method for treating ocular tissue within a localized portion of an eye during eye surgery with a pharmacological solution, the method comprising:
- delivering a pharmacological solution to ocular tissue within a portion of an eye; and
altering the effectiveness of at least some of the pharmacological solution on treatment of ocular tissue within said portion by applying a high-intensity pulsed electrical field to said at least some solution, using a high-intensity pulsed-electrical-field (HIPEF) probe.
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Accused Products
Abstract
A high-intensity pulsed-electrical-field (HIPEF) apparatus treats ocular tissue within a localized portion of an eye with a pharmacological solution. To mitigate risk of damage to adjacent, healthy ocular tissue, the apparatus delivers the solution to only a portion of the eye and then alters the effectiveness of at least some of the solution delivered by applying a HIPEF. In some embodiments, for example, the apparatus delivers an inactive pharmacological solution and then activates at least some of the solution by applying a HIPEF to that solution. As the apparatus applies the HIPEF with high precision, the HIPEF only activates solution within select portions of the eye. In other embodiments, the apparatus delivers a pharmacological carrier encapsulating an active pharmacological solution and then penetrates the carrier by applying a HIPEF. Delivered with a high concentration, but low dose, the solution diffuses only to tissue within a localized portion of the eye.
109 Citations
18 Claims
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1. A method for treating ocular tissue within a localized portion of an eye during eye surgery with a pharmacological solution, the method comprising:
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delivering a pharmacological solution to ocular tissue within a portion of an eye; and altering the effectiveness of at least some of the pharmacological solution on treatment of ocular tissue within said portion by applying a high-intensity pulsed electrical field to said at least some solution, using a high-intensity pulsed-electrical-field (HIPEF) probe. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A high-intensity pulsed-electrical-field (HIPEF) apparatus for treating ocular tissue within a localized portion of an eye during eye surgery with a pharmacological solution, the HIPEF apparatus comprising:
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an irrigation system configured to deliver a pharmacological solution to ocular tissue within a portion of an eye; and a HIPEF probe configured to alter the effectiveness of at least some of the pharmacological solution on treatment of ocular tissue within said portion by applying a high-intensity pulsed electrical field to said at least some solution. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification