COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON
First Claim
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1. A balloon for delivery of a therapeutic agent, the balloon comprising:
- a body having an outer surface; and
a tunable coating disposed on at least a length of the outer surface, the tunable coating including a first therapeutic agent and a first excipient having a first dissolution rate, and a second therapeutic agent and a second excipient having a second dissolution rate different from the first dissolution rate to define a tunable solubility.
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Abstract
A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
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Citations
51 Claims
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1. A balloon for delivery of a therapeutic agent, the balloon comprising:
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a body having an outer surface; and a tunable coating disposed on at least a length of the outer surface, the tunable coating including a first therapeutic agent and a first excipient having a first dissolution rate, and a second therapeutic agent and a second excipient having a second dissolution rate different from the first dissolution rate to define a tunable solubility. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A balloon for delivery of a drug, the balloon comprising:
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a body having an outer surface; and a tunable coating disposed on at least a length of the outer surface, the tunable coating including a cytostatic drug and at least one excipient, the tunable coating having a dissolution rate of about 10 s to about 1 h. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A balloon for delivery of a drug, the balloon comprising
a body having an outer surface; - and
a tunable coating disposed on at least a length of the outer surface, the tunable coating including a cytostatic drug and at least one excipient, wherein the cytostatic drug to excipient weight ratio is from about 20;
1 to about 1;
20. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45)
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46. A balloon for delivery of a drug, the balloon comprising
a body having an outer surface; - and
a tunable coating disposed on at least a length of the outer surface, the tunable coating including a cytostatic drug and at least one polymeric excipient, wherein the at least one polymeric excipient has a polydispersity index from about 1.05 to about 10. - View Dependent Claims (47, 48, 49, 50, 51)
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Specification