BONE GRAFT MATERIAL

• US 20110144764A1
• Filed: 10/28/2010
• Published: 06/16/2011
• Est. Priority Date: 10/29/2009
• Status: Abandoned Application

• Current Assignee: Prosidyan Incorporated
• Original Assignee: Prosidyan Incorporated
• Inventors: BAGGA, CHARANPREET S., Bae, Hyun W., Day, Thomas E.
• Application Number:
  US12/914,772
• Publication Number:
  US 20110144764A1
• Time in Patent Office: Days
• US Class Current: 623/23.61
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2002/30011 differing in porosity
• CPC Class Codes: A61F 2002/30032 differing in absorbability or resorbability, i.e. in absorption or resorption time
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61F 2250/003 differing in adsorbability or resorbability, i.e. in adsorption or resorption time
• CPC Class Codes: A61F 2310/00329 Glasses, e.g. bioglass
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders

Abstract

The present disclosure relates to a bone graft material and a bone graft implant formed from the material. In some embodiments, the bone graft implant comprises a porous matrix having a plurality of overlapping and interlocking bioactive glass fibers and a plurality of pores dispersed throughout the matrix, whereby the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter. The implant may be formed into a desired shape for a clinical application. The embodiments may be employed to treat a bone defect. For example, the bone graft material may be wetted and molded into a suitable form for implantation. The implant may then be introduced into a prepared anatomical site.

Claims

1. A bone graft implant comprising:

a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and a plurality of pores distributed throughout the matrix;

wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers;

wherein the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter; and

wherein the implant is formed into a desired shape for a clinical application.

2. The bone graft implant of claim 1, wherein the fibers have a diameter ranging from about 500 nanometers to about 20 micrometers.

3. The bone graft implant of claim 1, wherein the fibers are characterized by a uniform diameter.

4. The bone graft implant of claim 1, wherein the pores are characterized by a uniform diameter.

5. The bone graft implant of claim 1, further comprising a plurality of particulate distributed throughout the matrix.

6. The bone graft implant of claim 5, wherein the particulate includes interior lumens with perforations and provides the implant with a secondary range of porosity, while the plurality of pores of the matrix provide a primary range of porosity.

7. The bone graft implant of claim 5, wherein the particulate comprises bioactive glass, calcium sulfate, calcium phosphate, or hydroxyapatite.

8. The bone graft implant of claim 5, wherein the particulate includes roughened surfaces.

9. The bone graft implant of claim 1, wherein a component of the matrix is antimicrobial.

10. The bone graft implant of claim 9, wherein the antimicrobial component is alkaline.

11. The bone graft implant of claim 1, wherein the glass fibers are at least partially coated with one or more coating implant selected from the group including organic acids, mineralogical calcium sources, antimicrobials, antivirals, vitamins, glycerin, collagen, saline, and x-ray opacifiers.

12. The bone graft implant of claim 1, further comprising additives distributed throughout the matrix, wherein the additives are selected from the group including trace elements, organic acids, mineralogical calcium sources, medicines, antimicrobials, antivirals, vitamins, and x-ray opacifiers.

13. The bone graft implant of claim 1, further comprising a porosity gradient across the porous matrix.

14. The bone graft implant of claim 13, wherein the porosity gradient is configured to variably affect resorption of portions of the bone graft implant.

15. The bone graft implant of claim 1, further comprising collagen.

16. The bone graft implant of claim 1, wherein the implant is in the form of a foam.

17. The bone graft implant of claim 16, wherein the foam is in the form of a strip, a continuous rolled sheet, a sponge, or a plug.

18. The bone graft implant of claim 1, wherein the implant is in the form of a putty.

19. The bone graft implant of claim 1, wherein the fibers are in the form of hollow tubes.

20. The bone graft implant of claim 1, further comprising calcium phosphate.

21. The bone graft implant of claim 20, wherein the calcium phosphate is porous.

22. The bone graft implant of claim 1, further comprising tricalcium phosphate.

23. The bone graft implant of claim 22, wherein the tricalcium phosphate is porous.

24. The bone graft implant of claim 1, further comprising silver.

25. The bone graft implant of claim 1, further comprising carboxymethylcellulose or sodium alginate.

26. A method of treating a bone defect, the method comprising:

providing a bone graft implant, wherein the bone graft implant comprises a porous scaffold a porous scaffold comprising a plurality of overlapping and interlocking bioactive glass fibers, and a plurality of pores distributed throughout the scaffold, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter;

preparing an anatomical site to be treated to receive the bone graft implant; and

introducing the bone graft implant into the bone defect.

27. The method of claim 26, further comprising treating the porous scaffold of the bone graft implant to make it moldable.

28. The method of claim 27, wherein treating the porous scaffold comprises wetting the scaffold with a flowable solution.

29. The method of claim 28, wherein the flowable solution is saline.

30. The method of claim 29, wherein the flowable solution is a natural body fluid.

31. The method of claim 30, wherein the natural body fluid contains blood cells.

32. The method of claim 28, further comprising molding the wetted, porous scaffold into a desired shape to form the bone graft implant suitable for introduction into the bone defect.