P0WDER-FREE GLOVE WITH STABLE AND FAST ACTING MICROBIAL COATING

• US 20110145975A1
• Filed: 12/21/2010
• Published: 06/23/2011
• Est. Priority Date: 12/21/2009
• Status: Abandoned Application

• Current Assignee: Ansell Healthcare Products LLC (Ansell Limited)
• Original Assignee: Ansell Limited
• Inventors: Eng, Aik Hwee, Wan Ahmad, Wan Ashruzi, Tang, Lok Si, Lucas, David M.
• Application Number:
  US12/974,296
• Publication Number:
  US 20110145975A1
• Time in Patent Office: Days
• US Class Current: 2/161.7
• CPC Class Codes: A41D 19/0058 Three-dimensional gloves
• CPC Class Codes: A41D 19/015 Protective gloves A41D19/0055 takes precedence
• CPC Class Codes: A41D 31/305 using layered materials
• CPC Class Codes: A61B 42/00 Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof

Abstract

Provided, among other things, is a elastomeric medical glove having an antimicrobial surface coating comprising: a polymeric layer, and a dried, non-tacky coating on a surface of the polymeric layer, the coating comprising an antimicrobial agent, a wax agent, a lubricant, and a water-soluble wetting agent; wherein the glove comprises a residual powder of less than 2 mg per glove.

Claims

1. An elastomeric medical glove having an antimicrobial surface coating comprising:

a polymeric layer, and

a dried, non-tacky coating on a surface of the polymeric layer, the coating comprising an cationic antimicrobial agent, a wax agent, a lubricant, and a water-soluble wetting agent;

wherein the glove comprises a residual powder of less than 2 mg per glove.

2. The glove of claim 1, wherein the antimicrobial agent comprises poly(hexamethylene biguanide) chloride (PHMB), the wax agent comprises a polypropylene wax, the lubricant comprises a polysiloxane, and the water soluble wetting agent comprises alkyl trimethyl ammonium bromide.

3. The glove of claim 1, wherein the coating is formed from an aqueous solution of poly(hexamethylene biguanide) chloride in an amount in the range of 0.5 to 3.0% by weight, a polypropylene wax in an amount in the range of 0.05 to 1% by weight, an aminofunctional siloxane in an amount in the range of 0.05 to 1%, and alkyl trimethyl ammonium bromide in an amount in the range of 0.05% to 1%.

4. The glove of claim 1, wherein the polymeric layer comprises a polymeric material selected from the group consisting of natural rubber, synthetic rubber, and blends of natural and synthetic rubber.

5. The glove of claim 4, wherein the synthetic rubber is a nitrile rubber.

6. The glove of claim 4, wherein the synthetic rubber is polychloroprene, carboxylated acrylonitrile butadiene, styrene-butadiene, polyisoprene, polyurethane, polyvinyl chlorides, silicone rubber, styrene-butadiene-styrene block copolymer, styrene-isoprene-styrene block copolymer, styrene-isoprene block copolymer, styrene-butadiene block copolymer or a combination thereof.

7. The glove of claim 1, wherein the antimicrobial agent comprises a biguanide.

8. The glove of claim 7, wherein the biguanide comprises poly(hexamethylene biguanide) chloride (PHMB).

9. The glove of claim 1, wherein the water-soluble wetting agent comprises alkyl trimethyl ammonium bromide.

10. The glove of claim 1, wherein the lubricant comprises an aminofunctional siloxane.

11. The glove of claim 1, wherein the polymeric layer is a nitrile rubber and the coating comprises poly(hexamethylene biguanide) chloride (PHMB), a polypropylene wax, alkyl trimethyl ammonium bromide, and an aminofunctional siloxane.

12. The glove of claim 1, wherein the coating provides at least a 5 log reduction in Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 11229) after a 2 minute exposure.

13. The glove of claim 12 that has such an antimicrobial coating after storage for 10 days of accelerated aging at 70°

C.

14. The glove of claim 12 that has such an antimicrobial coating after storage for 90 days of accelerated aging at 50°

C.

15. A method of reducing microbial load during medical procedures, the method comprising wearing the elastomeric medical glove of claim 1, wherein the dried, non-tacky coating is on an inner surface of the glove.

16. The method of claim 15, wherein the coating provides at least a 5 log reduction in Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 11229) after a 2 minute exposure after storage for 10 days of accelerated aging at 70°

C. and after storage for 90 days at 50°

C.

17. A method of making an elastomeric medical glove comprising:

providing a polymeric glove,

applying an aqueous solution to a surface of the glove, the aqueous solution comprising an antimicrobial agent, a wax agent, a lubricant, and a water-soluble wetting agent; and

drying the aqueous solution to form a dried, non-tacky antimicrobial coating on the surface of the glove;

wherein the glove comprises a residual powder of less than 2 mg per glove.

18. The method of claim 17, wherein the polymeric latex glove comprises a nitrile and the coating comprises poly(hexamethylene biguanide) chloride (PHMB), a polypropylene wax, alkyl trimethyl ammonium bromide, and an aminofunctional siloxane.

19. The method of claim 17 further comprising storing the glove and achieving at least a 5 log reduction in Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 11229) after a 2 minute exposure.

20. The method of claim 19, wherein the 5 log reduction is achieved after storage for 10 days at 70°

C. and after storage for 90 days at 50°

C.