Method and apparatus for processing electrochemical signals

• US 20110147210A1
• Filed: 10/21/2010
• Published: 06/23/2011
• Est. Priority Date: 01/15/2002
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Iyengar, Sridhar G., Bolon, Craig, Haas, Daniel, Harding, Ian
• Granted Patent: US 8,303,787 B2
• Time in Patent Office: Days
• US Class Current: 204/403.14
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.

Claims

1-44. -44. (canceled)

45. In an apparatus for monitoring a select analyte in a mixed sample with an interfering analyte, the improvement wherein the apparatus comprises means for applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal;

and for resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.

46. An apparatus comprising:

a potentiostat circuit for applying a voltage waveform to and detecting a resulting current from an electrode system;

at least one memory having program instructions and a processor configured to execute the program instructions to perform the operations of;

applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal;

measuring the generated signal;

computing at least one Fourier coefficient of a desired frequency component of all or some portion of the generated signal; and

determining a concentration of the select analyte in the mixed sample by use of the at least one Fourier coefficient to resolve an estimation equation based on analyte vectors for each of the select and interfering analytes, wherein the electrode system comprises a biological recognition element.

47. The apparatus of claim 46, wherein the biological recognition element is an enzyme.