CHARGED PARTICLE CANCER THERAPY IMAGING METHOD AND APPARATUS

• US 20110147608A1
• Filed: 02/23/2011
• Published: 06/23/2011
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Granted Patent: US 8,519,365 B2
• Time in Patent Office: Days
• US Class Current: 250/396.R
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention relates to a method and apparatus for treatment of a solid tumor. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. In one embodiment, the tumor is imaged from multiple directions in phase with patient respiration. The two-dimensional images are combined to produce a three-dimensional picture of the tumor relative to patient features. The resulting three-dimensional image is used in generation of a radiation treatment plan and subsequent radiation therapy with the radiation beam in terms of control of two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, and/or beam velocity each as a function of patient vertical translation position, patient rotation position, and/or patient respiration.

Claims

1. An apparatus for imaging a patient, the patient having a variable respiration rate during an irradiation period, said apparatus comprising:

a statically positioned X-ray source;

a respiration sensor configured to generate a respiration signal, said respiration signal corresponding to a respiration pattern of the patient, said respiration pattern representing the variable respiration rate of the patient;

a rotatable platform configured to both (1) support the patient and (2) rotate the patient; and

means for collecting a set of X-ray images during the irradiation period, said set of X-ray images collected during a set of rotation positions of said rotatable platform, said set of rotation positions comprising at least five rotation positions covering at least ninety degrees of rotation,

wherein at least five X-ray images of said set of X-ray images represent X-ray images of the patient at said at least five rotation positions of said rotatable platform, and

wherein each of said five X-ray images represent a set time period of a respiration cycle occurring during one of said five rotation positions.

2. The apparatus of claim 1, further comprising:

an X-ray controller configured to generate a three-dimensional X-ray image of the patient using said set of X-ray images.

3. The apparatus of claim 1, said set of rotation positions comprising at least one hundred rotation positions,

wherein at least one hundred X-ray images of said set of X-ray images represent X-ray images of the patient at at least one hundred rotation positions of said rotatable platform, and

wherein each of said one hundred X-ray images represent a set time period of a respiration cycle occurring during one of said one hundred rotation positions.

4. The apparatus of claim 1, further comprising:

a charged particle beam system comprising a proton beam path, wherein during use protons travel along the proton beam path, wherein during use X-rays from said X-ray source travel along an X-ray beam path, wherein the proton beam path and the X-ray beam path comprise substantially parallel paths when entering the patient.

5. The apparatus of claim 1, said charged particle beam system further comprising:

a charged particle beam system comprising a synchrotron; and

a charged particle controller, said charged particle controller configured to dynamically adjust timing of extraction of charged particles from said synchrotron to occur in synchronization with the variable respiration rate of the patient over a period of at least three sequential respiration cycles represented by said respiration pattern, said three sequential respiration cycles comprising three different time lengths.

6. The apparatus of claim 5, said charged particle beam system further comprising:

at least one hand grip configured for gripping by the patient, said hand grip further comprising a button, said button configured to shut down at least a portion of said charged particle beam system.

7. The apparatus of claim 5, said synchrotron comprising:

a set of turning sections, wherein at least one turning section of said set of turning sections comprises at least four bending magnets.

8. The apparatus of claim 7, said at least four bending magnets comprising at least eight edge focusing surfaces.

9. The apparatus of claim 7, each of said bending magnets comprising:

a gap, wherein during use protons run through said gap, and

a core, wherein said core terminates at said gap.

10. The apparatus of claim 9, said gap comprising:

a surface comprising a finish of less than about ten microns polish.

11. The apparatus of claim 1, further comprising:

a charged particle system, configured to deliver protons to the patient.

12. The apparatus of claim 11, said charged particle therapy system further comprising:

an active scanning system configured to scan the protons along at least three axes, said active scanning system comprising a focal spot of the protons of less than three millimeters diameter, wherein said three axes comprise;

a horizontal axis, a vertical axis, and an applied energy axis.

13. The apparatus of claim 11, said charged particle therapy system further comprising:

a velocity control system configured to variably alter a rate of scanning movement of the protons in a raster beam.

14. The apparatus of claim 11, said charged particle therapy system further comprising:

a particle beam controller configured to control an intensity controller, said intensity controller configured to use a measure of a current, resulting from the protons striking an extraction foil, as a feedback control to a radio-frequency cavity system.

15. The apparatus of claim 11, said charged particle therapy system further comprising:

a controller configured to change an x, y, and z-axis position of a focal spot of the protons with a first velocity, wherein the first velocity is adjusted to a second velocity while the raster beam continuously provides the protons.

16. A method for imaging a patient, the patient having a variable respiration rate, said method comprising the steps of:

statically positioning an X-ray source;

generating a respiration signal using a respiration sensor, said respiration signal corresponding to a respiration pattern of the patient, said respiration pattern representing the variable respiration rate of the patient;

during an irradiation period of the patient, rotating a rotatable platform both supporting the patient; and

collecting a set of X-ray images during the irradiation period, said set of X-ray images collected during a set of rotation positions of said rotatable platform, said set of rotation positions comprising at least five rotation positions covering at least ninety degrees of rotation,

wherein at least five X-ray images of said set of X-ray images represent X-ray images of the patient at said at least five rotation positions of said rotatable platform, and

wherein each of said five X-ray images represent a set time period of a respiration cycle occurring during one of said five rotation positions.

17. The method of claim 16, further comprising the steps of:

providing a charged particle irradiation system configured to generate charged particles;

generating at least one command with a respiration command controller, said controller using said respiration pattern to determine said at least one command; and

displaying said at least one command on a display screen configured to instruct the patient in respiration while the patient is positioned for irradiation therapy with the charged particles, said at least one command comprising a visual countdown timer, said timer informing the patient as to when to hold breath.

18. The method of claim 17, further comprising the steps of:

providing a synchrotron; and

controlling delivery of charged particles from said synchrotron at sequential non-periodic intervals, said non-periodic intervals correlating with said variable respiration rate, wherein said respiration pattern comprises at least two sequential respiration cycles varying by at least one second in length.

19. The method of claim 18, further comprising the step of:

dynamically adjusting a step of timing extraction of protons from said synchrotron to occur in synchronization with a changing respiration rate of the patient.

20. The method of claim 16, further comprising the step of:

controlling said variable respiration rate, said step of controlling using a signal generated by said respiration sensor and feedback respiration instructions provided to the patient on a display screen.