Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure

• US 20110150714A1
• Filed: 01/07/2011
• Published: 06/23/2011
• Est. Priority Date: 07/09/2009
• Status: Active Grant

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Schleiffer, Keith E., Graves, Todd L., Kolb, Hartmuth C., Miraghaie, Reza, Zhang, Jianzhong, Ball, Carroll Edward, Lebedev, Artem, Elizarov, Arkadij M.
• Granted Patent: US 8,435,454 B2
• Time in Patent Office: Days
• US Class Current: 422/159
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/0081 Plurality of modules
• CPC Class Codes: B01J 2219/00826 Quartz
• CPC Class Codes: B01J 2219/00831 Glass
• CPC Class Codes: B01J 2219/00833 Plastic
• CPC Class Codes: B01J 2219/0086 Dimensions of the flow channels
• CPC Class Codes: B01J 2219/00871 Modular assembly
• CPC Class Codes: B01J 2219/00873 Heat exchange
• CPC Class Codes: B01J 2219/00889 Mixing micromixers B01F33/30
• CPC Class Codes: B01J 2219/00905 Separation
• CPC Class Codes: B01J 2219/00936 UV-radiations

Abstract

Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Claims

1. An instrument for synthesis of radiolabeled compounds comprising:

one or more “

hot”

component units;

at least one “

cold”

component unit;

wherein the one or more “

hot”

component units and the at least one “

cold”

component unit are separate units that are operatively connected to each other, and the one or more “

hot”

component units and the at least one “

cold”

component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment; and

one or more cassette apparatus operatively coupled to a portion of the instrument, the one or more cassette apparatus adapted to provide at least a portion of contents of the one or more cassette apparatus to either one or more of the one or more hot component units or one or more of the at least one cold component units.

2. The instrument according to claim 1, wherein the one or more cassette apparatus include one or more disposable cassette apparatus.

3. The instrument according to claim 1, wherein the one or more cassette apparatus include one or more re-usable cassette apparatus.

4. The instrument according to claim 1, wherein the one or more cassette apparatus include one or more single-use cassette apparatus.

5. The instrument according to claim 1, wherein the one or more cassette apparatus include one or more multi-use cassette apparatus.

6. The instrument according to claim 1, wherein one or more of the one or more cassette apparatus are operatively coupled to one or more of the one or more hot component units.

7. The instrument according to claim 1, wherein one or more of the one or more cassette apparatus are operatively coupled to one or more of the at least one cold component units.

8. The instrument according to claim 1, wherein one or more of the one or more cassette apparatus are operatively coupled to one or more of the one or more hot component units, and include one or more disposable cassette apparatus.

9. The instrument according to claim 1, wherein one or more of the one or more cassette apparatus are operatively coupled to one or more of the cold component units, and include one or more disposable cassette apparatus.

10. The instrument according to claim 1, wherein one or more of the one or more cassette apparatus are operatively coupled to one or more of the one or more hot component units and one or more of the at least one cold component unit.

11. The instrument according to claim 1, further comprising:

radiation shielding disposed in proximity to one or more of the one or more hot component units to reduce radiation exposure.

12. The instrument according to claim 11, wherein one or more of the one or more cassette apparatus are operatively coupled to the instrument outside the radiation shielding.

13. The instrument according to claim 1, wherein the one or more cassette apparatus enable refilling of contents of the cassette apparatus without exposure to radiation.

14. The instrument according to claim 1, wherein at least one of the one or more cassette apparatus are pre-packaged.

15. A cassette device comprising:

a body portion;

at least one inlet port for receiving a fluid;

at least one outlet port for providing at least a portion of the fluid; and

one or more functional elements disposed on the body portion to perform an associated function.

16. The cassette device according to claim 15, wherein at least one of the functional elements are disposable.

17. The cassette device according to claim 15, wherein the body portion includes one or more reservoirs that are arranged so as to provide contents of the reservoirs in a predetermined sequence.

18. The cassette device according to claim 15, wherein the one or more functional elements include elements for the wetted path.

19. The cassette device according to claim 15, wherein the one or more functional elements include HPLC.

20. The cassette device according to claim 15, wherein the one or more functional elements include ion exchange.