IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN
First Claim
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1. A method of identifying compounds that reduce persistent pain in a mammal, comprising:
- providing one or more MrgprX1 agonists;
testing the MrgprX1 agonists for their ability to reduce persistent pain;
testing the MrgprX1 agonists for their ability to modulate acute pain; and
identifying the MrgprX1 agonists that have the ability to reduce persistent pain but do not significantly modulate acute pain.
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Abstract
The present application provides methods and compositions that can be used to treat persistent pain and to identify compounds that can be used for treating persistent pain. More specifically, agonists of members of the Mrgpr receptor family, particularly agonists of MrgprX1, can identified and screened for use in treating persistent pain, such as pain caused by inflammation or nerve injury.
8 Citations
24 Claims
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1. A method of identifying compounds that reduce persistent pain in a mammal, comprising:
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providing one or more MrgprX1 agonists; testing the MrgprX1 agonists for their ability to reduce persistent pain; testing the MrgprX1 agonists for their ability to modulate acute pain; and identifying the MrgprX1 agonists that have the ability to reduce persistent pain but do not significantly modulate acute pain. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating persistent pain in a subject, comprising:
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identifying a subject suffering from persistent pain; and administering to the subject an effective amount of an MrgprX1 agonist. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification