OPHTHALMIC SOLUTIONS WITH IMPROVED DISINFECTION PROFILES

• US 20110151017A1
• Filed: 12/17/2010
• Published: 06/23/2011
• Est. Priority Date: 12/17/2009
• Status: Abandoned Application

• Current Assignee: Alcon Research Limited (Nestle SA)
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Dassanayake, Nissanke L., Borazjani, Roya Nicole, Baker, John C., Carey, Thomas Christopher, Ketelson, Howard Allen, Davis, James W.
• Application Number:
  US12/972,095
• Publication Number:
  US 20110151017A1
• Time in Patent Office: Days
• US Class Current: 424/616
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/22 Boron compounds
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/08 containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61L 12/124 Hydrogen peroxide; Peroxy compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3947 Liquid compositions

Abstract

The present invention relates to ophthalmic solutions with antimicrobial activity. The solutions have an antimicrobial compound such as hydrogen peroxide and a boron compound. In one embodiment, the solutions contain a boron compound such as sodium borate that provides antimicrobial activity in addition to that of hydrogen peroxide, particularly during periods following disinfection and neutralization of such solutions. This additional activity reduces the likelihood of microbial growth in contact lens disinfection applications that neutralize hydrogen peroxide.

Claims

1. An ophthalmic composition comprising hydrogen peroxide and a boron compound, said composition having a pH of between 6.5 and 9.0.

2. A composition according to claim 1 having a hydrogen peroxide concentration of 0.1 to 3.5 w/v % and a boron compound selected from the group consisting of sodium borate, boric acid, and combinations thereof.

3. A composition according to claim 2, wherein the total boron concentration of said composition is between 0.05M and 0.15M.

4. A composition according to claim 1, said composition having a pH of 7.0 to 7.9.

5. A composition according to claim 1, said composition having a pH of 7.0 to 7.5.

6. A composition according to claim 1, said composition haying an osmolality of 210 to 320 mOsm/kg.

7. A composition according to claim 1, said composition being substantially free of surfactants.

8. A composition according to claim 1, said composition further comprising an indicator compound.

9. A composition according to claim 1, further comprising monobasic sodium phosphate, dibasic sodium phosphate, and sodium chloride.

10. An improved ophthalmic composition comprising hydrogen peroxide, said composition further comprising a concentration of boron sufficient to reduce or prevent microbial growth in the composition following neutralization of the hydrogen peroxide.

11. A composition according to claim 10, said composition having a pH of 7.0 to 7.5.

12. A composition according to claim 10, said composition having a total boron concentration of 0.10M to 0.15M.

13. A composition according to claim 12, said composition being substantially free of surfactants.

14. A composition according to claim 12, said composition further comprising an indicator compound.

15. In a method for disinfecting contact lenses comprising immersing a contact lens in an ophthalmic composition comprising hydrogen peroxide, the improvement consisting of immersing a contact lens in an ophthalmic composition comprising hydrogen peroxide and a boron compound, said boron compound present in a concentration sufficient to reduce or prevent microbial growth in the composition.

16. A method according to claim 15, wherein said composition has a total boron concentration of 0.05M to 0.15M.

17. A method according to claim 16, wherein said composition has a total boron concentration of 0.10M to 0.15M.

18. A method according to claim 17, wherein said composition is substantially free of surfactants.

19. A method according to claim 17, wherein said composition further comprises an indicator compound.

20. An ophthalmic composition consisting essentially of:

a) 3.0 w/v % hydrogen peroxide;

b) 0.33 w/v % sodium borate;

c) 0.41 w/v % boric acid;

d) 0.136 w/v % monobasic sodium phosphate;

e) 0.062 w/v % dibasic sodium phosphate;

f) 0.12 w/v % DEQUEST®

2060S;

g) 0.47 w/v % sodium chloride;

h) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.0; and

i) purified water.