COMPOSITIONS FOR ALLEVIATING INFLAMMATION AND OXIDATIVE STRESS IN A MAMMAL
First Claim
1. A composition comprising:
- 10 weight percent to 30 weight percent Bacopa monniera extract having at least 20 percent bacosides;
10 weight percent to 50 weight percent Silybum marianum (milk thistle) extract having between about 40 percent and about 90 percent silymarin;
10 weight percent to 30 weight percent Withania somnifera (ashwagandha) powder;
5 weight percent to 15 weight percent Camellia sinensis (green tea) extract, wherein said green tea extract is comprised of at least 40 percent epigallocatechin gallate and about 98% polyphenols; and
5 weight percent to 15 weight percent Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least 50 percent curcumin;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of;
superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
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Accused Products
Abstract
An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprising Bacopa monniera extract; milk thistle extract, ashwagandha powder, green tea extract, Gotu kola powder, Ginko biloba leaf extract; Aloe vera powder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.
22 Citations
13 Claims
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1. A composition comprising:
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10 weight percent to 30 weight percent Bacopa monniera extract having at least 20 percent bacosides; 10 weight percent to 50 weight percent Silybum marianum (milk thistle) extract having between about 40 percent and about 90 percent silymarin; 10 weight percent to 30 weight percent Withania somnifera (ashwagandha) powder; 5 weight percent to 15 weight percent Camellia sinensis (green tea) extract, wherein said green tea extract is comprised of at least 40 percent epigallocatechin gallate and about 98% polyphenols; and 5 weight percent to 15 weight percent Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least 50 percent curcumin; wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of;
superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A composition comprising:
- about 22 weight percent Bacopa monniera extract comprised of about 45 percent bacosides;
about 33 weight percent Silybum marianum (milk thistle) extract, wherein said milk thistle extract is comprised of between about 70 percent and about 80 percent silymarin;
about 22 weight percent Withania somnifera (ashwagandha) powder;
Camellia sinensis (green tea extract), wherein said green tea extract is comprised of 98 percent polyphenols;
said polyphenols comprised of 45 percent (−
)-epigallocatechin gallate;
Curcuma longa (turmeric) extract;
wherein said turmeric extract is comprised of about 95 percent curcumin;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of;
superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof. - View Dependent Claims (8)
- about 22 weight percent Bacopa monniera extract comprised of about 45 percent bacosides;
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9. A composition comprising:
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about 22 weight percent Bacopa monniera extract having 20 percent bacosides or greater; about 33 weight percent Silybum marianum (milk thistle) extract having between about 40 percent and about 90 percent silymarin; about 22 weight percent Withania somnifera (ashwagandha) powder; about 11 weight percent Camellia sinensis (green tea) extract, wherein said green tea extract is comprised of at least 40 percent epigallocatechin gallate and about 98% polyphenols; and about 11 weight percent Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least 50 percent curcumin; wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of;
superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof. - View Dependent Claims (10, 11, 12, 13)
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Specification