DEVICE AND METHOD FOR DETECTING PLAQUE IN THE ORAL CAVITY

• US 20110151409A1
• Filed: 12/23/2009
• Published: 06/23/2011
• Est. Priority Date: 12/23/2009
• Status: Active Grant

• Current Assignee: Johnson & Johnson Consumer Inc. (Johnson & Johnson)
• Original Assignee: McNeil-PPC Incorporated (Johnson & Johnson)
• Inventors: BINNER, Curt
• Granted Patent: US 8,314,377 B2
• Time in Patent Office: Days
• US Class Current: 433/215
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 1/0646 with illumination filters
• CPC Class Codes: A61B 1/0676 at distal tip of an endoscope
• CPC Class Codes: A61B 1/24 for the mouth, i.e. stomatoscopes, e.g. with tongue depressors tongue depressors per se A61B13/00; Instruments for opening or keeping open the mouth combined with saliva removers A61C17/00; mouth openers for animals A61D15/00
• CPC Class Codes: A61B 5/0088 for oral or dental tissue
• CPC Class Codes: G01N 2021/6484 Optical fibres
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 2201/0846 Fibre interface with sample, e.g. for spatial resolution

Abstract

The present invention regards methods and devices for detecting plaque on a surface in the oral cavity to which a fluorescent agent capable of binding to plaque has been applied, whereby a radiation source emits incident radiation for contacting the surface, reflected light and fluorescent emission resulting from contact of the radiation with the surface is collected by an optical collector and conveyed by an optical pathway in the device, where the optical light signal of the reflected light and fluorescent emission is converted to an electrical signal, and where the electrical signals of the fluorescent emission and the reflected light are then mathematically manipulated to provide a compensated plaque value as a function of the distance from the optical collector and the surface of the oral cavity to which the fluorescent agent has been applied.

Claims

1. A method for detecting plaque in the oral cavity, said method comprising:

contacting a surface of said oral cavity with incident radiation, said surface comprising applied thereto a fluorescent agent capable of binding to plaque, whereby said contact provides reflected light having a first wavelength and a fluorescent emission emanating from said fluorescent agent having a second wavelength,

collecting and conveying a first portion of said fluorescent emission resulting from said contact to a first means for converting an optical signal of said first fluorescent emission to an electrical signal of said first portion of fluorescent emission and converting said optical signal of said first portion of fluorescent emission to said electrical signal of said first portion of said fluorescent emission,

collecting and conveying a first portion of said reflected light to a second means for converting an optical signal of said first portion of said reflected light to an electrical signal of said first portion of said reflected light and converting said optical signal of said first portion of said reflected light to said electrical signal of said first portion of said reflected light; and

mathematically manipulating said electrical signal of said first portion of said fluorescent emission and said first portion of said reflected light to provide a compensated plaque value.

2. The method of claim 1 wherein said fluorescent agent comprises fluorescein or a salt thereof and said incident radiation has a peak wavelength of from about 450 to about 500 nanometers.

3. The method of claim 2 wherein said incident radiation is passed through a first optical filter prior to contact with said surface.

4. The method of claim 3 wherein said incident radiation has a wavelength of about 470 nanometers.

5. The method of claim 1 wherein a second portion of said reflected light is simultaneously collected and conveyed with said first portion of said fluorescent emission through a second optical filter prior to conversion of said optical signal of said fluorescent emission to said electrical signal of said fluorescent emission, said second filter removing light having a wavelength of below about 515 nanometers.

6. The method of claim 1 wherein said electrical signal of said fluorescent emission and said reflected light are amplified prior to said mathematical manipulation.

7. The method of claim 1 wherein said electrical signal of said fluorescent emission and said reflected light are converted to a digital format prior to said mathematical manipulation.

8. The method of claim 1 wherein a second portion of said fluorescent emission is simultaneously conveyed with said first portion of said reflected light.

9. The method of claim 1 wherein said conveyance of said first portions of said fluorescent emission and reflected light is substantially simultaneous.

10. The method of claim 1 wherein said fluorescent emission comprises a peak wavelength of from about 520 to about 530 nanometers.

11. The method of claim 1 wherein said reflected light and said fluorescent emission are collected and conveyed by optical fibers.

12. The method of claim 7 wherein said first portion of said reflected light is simultaneously conveyed with said second portion of said fluorescent emission through a third optical filter prior to conversion of said optical signal of said fluorescent emission to said electrical signal of said fluorescent emission, said third filter removing light having a wavelength of above about 515 nanometers.

13. The method of claim 1 wherein said compensated plaque value is determined as a function of the distance between said point of collection of said fluorescent emission and said surface of said oral cavity.

14. A device for detecting plaque on a surface of the oral cavity, said device comprising:

a radiation source for directing incident radiation onto said surface of said oral cavity,

optical collectors for collecting reflected light and fluorescent emission,

optical pathways for conveying said collected reflected light and said collected fluorescent emission in said device,

means for converting an optical light signal of said reflected light and said fluorescent emission to an electrical signal; and

means for mathematically manipulating said electrical signal of said reflected light and said fluorescent emission to determine a compensated plaque value.

15. The device of claim 14 wherein said optical collectors comprise an optical fiber.

16. The device of claim 14 wherein said optical pathway comprises an optical fiber.

17. The device of claim 15 wherein said optical pathway comprises said optical fiber.

18. The device of claim 14 wherein said means for converting said optical light signal of said reflected light and fluorescent emission to said electrical signal comprises an optical transducer.

19. The device of claim 14 further comprising means for amplifying or conditioning said electrical signal of said reflected light and said fluorescent emission.

20. The device of claim 14 further comprising a first optical filter through which said incident radiation is passed prior to contact with said surface.

21. The device of claim 14 further comprising a second optical filter through which a second portion of said reflected light and a first portion of said fluorescent emission is conveyed prior to conversion of said optical light signal to said electrical signal.

22. The device of claim 14 further comprising a third optical filter through which a first portion of said reflected light and a second portion of said fluorescent emission is conveyed prior to conversion of said optical light signal to said electrical signal.

23. The device of claim 14 wherein said means for mathematically manipulating said electrical signal of said reflected light and said fluorescent emission comprises a data processor, said data processor further comprising an analogue-to-digital converter for converting said electrical signal of said reflective light and said fluorescent emission from an analogue format to a digital format prior to manipulation of said electrical signal.