Portable Coagulation Monitoring Device and Method of Assessing Coagulation Response
First Claim
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1. A device for measuring coagulation response in a blood sample, comprising:
- a first member having a first surface, and a second member having a second surface, said first member positioned for having said first surface facing said second surface of said second member, and spaced an amount sufficient to allow a sample droplet of blood to contact said first surface and said second surface and initiate coagulation, and said first member and second member being linearly movable relative to each other;
a drive mechanism connected to at least one of said first member and said second member for linearly moving said first member and said second member relative to each other in parallel when a blood sample is in contact with said first surface and said second surface; and
an optical detection sensor system for detecting interaction of light with a blood sample located between said first member and second member, as an indication of coagulation response of said blood sample.
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Abstract
A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof.
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Citations
31 Claims
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1. A device for measuring coagulation response in a blood sample, comprising:
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a first member having a first surface, and a second member having a second surface, said first member positioned for having said first surface facing said second surface of said second member, and spaced an amount sufficient to allow a sample droplet of blood to contact said first surface and said second surface and initiate coagulation, and said first member and second member being linearly movable relative to each other; a drive mechanism connected to at least one of said first member and said second member for linearly moving said first member and said second member relative to each other in parallel when a blood sample is in contact with said first surface and said second surface; and an optical detection sensor system for detecting interaction of light with a blood sample located between said first member and second member, as an indication of coagulation response of said blood sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of measuring coagulation response in a blood sample, comprising:
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placing a sample droplet of blood between and in contact with first and second facing surfaces of oppositely disposed substantially parallel plates; moving at least one plate linearly with respect to the other plate at a predetermined speed; and optically detecting coagulation response of the droplet of blood by measuring mechanical interaction between the first and second surfaces resulting from changes in the viscosity of the sample fluid and binding to the plate surfaces. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of measuring coagulation response in a blood sample comprising:
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placing a sample droplet of blood between and in contact with facing surfaces of oppositely disposed plates; moving at least one plate linearly with respect to the other plate at a first speed; optically detecting a first coagulation response of the blood indicative of platelet response in the blood; moving at least one plate linearly with respect to the other plate at a second speed; and optically detecting a second coagulation response of the blood indicative of fibrin polymerization. - View Dependent Claims (31)
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Specification