Functional molecule and manufacturing method therefor
First Claim
1. A method for manufacturing a functional molecule, comprising:
- binding, to a resin, a specific substance having a cleavable linker which is a site that is cleavable under a specific condition to prepare a specific-substance-bound resin;
treating said specific-substance-bound resin with a solution comprising functional molecule candidates; and
cleaving said cleavable linker under said specific condition and selecting a functional molecule which has interacted specifically with said specific substance;
wherein said functional molecule is a modified nucleotide n-mer (n≧
2) comprising a modified nucleoside having a substituent group introduced into a nucleoside constituting a nucleic acid, andwherein said functional molecule can be transformed into a nucleic acid when said substituent group is removed by alkali treatment.
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Accused Products
Abstract
A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule manufactured by this method. The method for manufacturing a functional molecule includes binding, to a resin, a specific substance having a cleavable linker which is a site that is cleavable under a specific condition to prepare a specific-substance-bound resin, treating this specific-substance-bound resin with a solution comprising functional molecule candidates, and then cleaving the cleavable linker under the specific condition to select a functional molecule which has interacted specifically with the specific substance.
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Citations
9 Claims
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1. A method for manufacturing a functional molecule, comprising:
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binding, to a resin, a specific substance having a cleavable linker which is a site that is cleavable under a specific condition to prepare a specific-substance-bound resin; treating said specific-substance-bound resin with a solution comprising functional molecule candidates; and cleaving said cleavable linker under said specific condition and selecting a functional molecule which has interacted specifically with said specific substance; wherein said functional molecule is a modified nucleotide n-mer (n≧
2) comprising a modified nucleoside having a substituent group introduced into a nucleoside constituting a nucleic acid, andwherein said functional molecule can be transformed into a nucleic acid when said substituent group is removed by alkali treatment. - View Dependent Claims (8)
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2-7. -7. (canceled)
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9-10. -10. (canceled)
Specification