Bionanomaterials and Their Synthesis

• US 20110151542A1
• Filed: 09/16/2010
• Published: 06/23/2011
• Est. Priority Date: 11/01/2005
• Status: Active Grant

• Current Assignee: University of South Carolina
• Original Assignee: University of South Carolina
• Inventors: Wang, Qian, Niu, Zhongwei
• Granted Patent: US 8,334,127 B2
• Time in Patent Office: Days
• US Class Current: 435/235.1
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C12N 2770/00023 Virus like particles [VLP]
• CPC Class Codes: C12N 7/00 Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00
• CPC Class Codes: D01F 1/10 Other agents for modifying properties
• CPC Class Codes: D01F 6/76 from other polycondensation products
• CPC Class Codes: Y10S 977/762 Nanowire or quantum wire, i.e. axially elongated structure having two dimensions of 100 nm or less

Abstract

The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.

Claims

1-24. -24. (canceled)

25. A 1-dimensional composite nanofiber comprising:

a plurality of rod-like viruses, wherein each rod-like virus defines a head and a tail, and wherein the plurality of rod-like viruses are assembled in a wire-like structure such that the head of one rod-like virus is adjacent to the tail of an adjacent virus; and

a polymer surrounding the wire-like structure to fix the plurality of rod-like viruses together in the wire-like structure, wherein the polymer comprises a plurality of monomers having a thiol group.

26. The composite nanofiber as in claim 25, wherein the rod-like viruses comprise tobacco mosaic viruses.

27. The composite nanofiber as in claim 26, wherein the tobacco mosaic viruses comprise wild-type tobacco mosaic viruses.

28. The composite nanofiber as in claim 25, wherein the rod-like viruses comprise functionalized rod-like viruses.

29. The composite nanofiber as in claim 28, wherein the functionalized rod-like viruses comprise o-toluenesulfonic acid modified tobacco mosaic viruses.

30. The composite nanofiber as in claim 28, wherein the functionalized rod-like viruses comprise alkyne-functional rod-like viruses.

31. A 1-dimensional composite nanofiber comprising:

a plurality of functionalized rod-like viruses, wherein each functionalized rod-like virus defines a head and a tail, and wherein the plurality of functionalized rod-like viruses are assembled in a wire-like structure such that the head of one functionalized rod-like virus is adjacent to the tail of an adjacent virus, wherein the functionalized rod-like viruses comprise o-toluenesulfonic acid modified tobacco mosaic viruses; and

a polymer surrounding the wire-like structure to fix the plurality of rod-like viruses together in the wire-like structure.

32. The composite nanofiber as in claim 31, wherein the polymer comprises a plurality of positively charged monomers.

33. The composite nanofiber as in claim 31, wherein the polymer comprises a plurality of monomers having an amino group.

34. The composite nanofiber as in claim 31, wherein the polymer comprises aniline monomers.

35. The composite nanofiber as in claim 31, wherein the polymer comprises polyaniline.

36. The composite nanofiber as in claim 31, wherein the polymer comprises polyaniline, polypyrrole, polythiophene, polyethylenedioxythiophene, polypyrazole, or derivatives or copolymers thereof.

37. A 1-dimensional composite nanofiber comprising:

a plurality of functionalized rod-like viruses, wherein each functionalized rod-like virus defines a head and a tail, and wherein the plurality of functionalized rod-like viruses are assembled in a wire-like structure such that the head of one functionalized rod-like virus is adjacent to the tail of an adjacent virus, wherein the functionalized rod-like viruses comprise alkyne-functional rod-like viruses; and

a polymer surrounding the wire-like structure to fix the plurality of rod-like viruses together in the wire-like structure.

38. The composite nanofiber as in claim 37, wherein the polymer comprises a plurality of positively charged monomers.

39. The composite nanofiber as in claim 37, wherein the polymer comprises a plurality of monomers having an amino group.

40. The composite nanofiber as in claim 37, wherein the polymer comprises aniline monomers.

41. The composite nanofiber as in claim 37, wherein the polymer comprises polyaniline.

42. The composite nanofiber as in claim 37, wherein the polymer comprises polyaniline, polypyrrole, polythiophene, polyethylenedioxythiophene, polypyrazole, or derivatives or copolymers thereof.