POLYMORPHS OF (S)-3-AMINOMETHYL-7-(3-HYDROXY-PROPOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL
First Claim
Patent Images
1. A crystalline polymorph characterized by having essentially any of the °
- 2θ
values listed in Table 1±
0.2°
2θ
;
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Abstract
This invention provides, among other things, polymorphs of the hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.
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Citations
20 Claims
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1. A crystalline polymorph characterized by having essentially any of the °
- 2θ
values listed in Table 1±
0.2°
2θ
;
- View Dependent Claims (2, 3, 4, 5, 6, 10, 11, 12, 13, 14, 15)
- 2θ
-
7. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol having, upon X-ray crystallographic analysis, crystal parameters of substantially the following values:
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Crystallographic system;
orthorhombicSpace group;
P212121Crystal dimensions;
a=9.1045(2) Å
, b=10.3107(2) Å
, c=14.5988(3) Å
α
=90.00°
, β
=90.00°
, γ
=90.00°Volume 1370.44(5) A3 Z, calculated density 4, 1.326 g cm−
3.
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8. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol, characterized by having a
upon Raman spectroscopic analysis, any of the peaks having substantially the wavenumbers (cm− - 1) selected from the group consisting of 3076.4, 3054.6, 2987.4, 2975.5, 2954.2, 2928.0, 2909.8, 2896.0, 1578.6, 1298.2, 1291.6, 1263.0, 1226.8, 1068.9, and 694.9, ±
50 wave numbers. - View Dependent Claims (9)
- 1) selected from the group consisting of 3076.4, 3054.6, 2987.4, 2975.5, 2954.2, 2928.0, 2909.8, 2896.0, 1578.6, 1298.2, 1291.6, 1263.0, 1226.8, 1068.9, and 694.9, ±
- 16. Crystalline (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl, form HCl4.
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17. Crystalline (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl, form HCl3.
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18. Crystalline (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl, form HCl2.
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19. Crystalline (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl, form HCl1.
Specification